Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors

被引：34
|
作者：
Vindis, Cecile [1 ]
D'Angelo, Romina [2 ]
Mucher, Elodie [1 ]
Negre-Salvayre, Anne [1 ]
Parini, Angelo [3 ]
Mialet-Perez, Jeanne [3 ]
机构：
[1] CHU Rangueil, INSERM, U 858 12MR, IFR 150,Dept Vasc Biol, F-31054 Toulouse, France
[2] CHU Rangueil, INSERM, U 858 12MR,Cellular Imaging Facil, IFR 150 TRI Plateform, F-31054 Toulouse, France
[3] CHU Rangueil, INSERM, U 858 12MR, IFR 150,Dept Cardiac Remodeling, F-31054 Toulouse, France
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 01期
关键词：
5-HT2A receptors; 5-HT; TRPC; NFAT; Cardiac hypertrophy; CARDIOMYOCYTE HYPERTROPHY; VENTRICULAR HYPERTROPHY; POTENTIAL CHANNELS; ANGIOTENSIN-II; ACTIVATION;
D O I：
10.1016/j.bbrc.2009.12.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Serotonin (5-HT) paiticipates in the development of cardiac hypertrophy through 5-HT2A serotonin receptors. The hypertrophic growth of cardiomyoblasts induced by 5-HT2A receptors involves the activation of the Ca2+ responsive calcineurin/NFAT pathway However, the mechanism whereby NFAT is activated by 5-HT2A receptors remains indeterminate In this study, we examined whether transient receptor potential canonical (TRPC) channels participate in NFAT activation and hypertrophic response triggered by 5-HT We demonstrate that TRPC1 expression is upregulated in 5-HT-treated rat cardiomyoblasts whereas TRPC6 is induced in a mouse Model of heart hypertrophy Moreover, TRPC1 knockdown by small interfering RNA inhibits NFAT activation and hypertrophic response mediated by 5-HT2A receptors These findings provide new insights about a mechanistic basis for the activation of the calcineurin/NFAT pathway by 5-HT2A receptors and highlight the critical role of TRPC1 in the development of cardiac hypertrophy. (C) 2009 Elsevier Inc. All rights reserved
引用
收藏
页码：979 / 983
页数：5
相关论文
共 38 条
  • [1] Serotonin 5-HT2A receptor-mediated hypertrophy is negatively regulated by caveolin-3 in cardiomyoblasts and neonatal cardiomyocytes
    Mialet-Perez, Jeanne
    D'Angelo, Romina
    Villeneuve, Christelle
    Ordener, Catherine
    Negre-Salvayre, Anne
    Parini, Angelo
    Vindis, Cecile
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (02) : 502 - 510
  • [2] Role of serotonin 5-HT2A receptors in the development of cardiac hypertrophy in response to aortic constriction in mice
    Lairez, O.
    Cognet, T.
    Schaak, S.
    Calise, D.
    Guilbeau-Frugier, C.
    Parini, A.
    Mialet-Perez, J.
    JOURNAL OF NEURAL TRANSMISSION, 2013, 120 (06) : 927 - 935
  • [3] Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels
    Aykanat, Nuriye Ezgi Bektur
    Sahin, Erhan
    Kacar, Sedat
    Bagci, Ridvan
    Karakaya, Serife
    Donmez, Dilek Burukoglu
    Sahinturk, Varol
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021, 99 (11) : 1226 - 1233
  • [4] The role of 5-HT2A receptor and 5-HT2A/5-HT1A receptor interaction in the suppression of catalepsy
    Naumenko, V. S.
    Bazovkina, D. V.
    Kondaurova, E. M.
    Zubkov, E. A.
    Kulikov, A. V.
    GENES BRAIN AND BEHAVIOR, 2010, 9 (05) : 519 - 524
  • [5] On the Functional Cross-Talk between Brain 5-HT1A and 5-HT2A Receptors
    Naumenko, V. S.
    Bazovkina, D. V.
    Kondaurova, E. M.
    ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2015, 65 (02) : 240 - 247
  • [6] Serotonin 5-HT2A and 5-HT2C receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms
    Gao, Jun
    Nie, Lina
    Li, Yu
    Li, Ming
    NEUROPHARMACOLOGY, 2020, 162
  • [7] Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
    Brattelid, T.
    Qvigstad, E.
    Birkeland, J. A. K.
    Swift, F.
    Bekkevold, S. V. S.
    Krobert, K. A.
    Sejersted, O. M.
    Skomedal, T.
    Osnes, J. -B
    Levy, F. O.
    Sjaastad, i
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 101 : 74 - 74
  • [8] Obligatory role for PKCδ in PIP2-mediated activation of store-operated TRPC1 channels in vascular smooth muscle cells
    Baudel, Miguel A. S. Martin-Aragon
    Shi, Jian
    Large, William A.
    Albert, Anthony P.
    JOURNAL OF PHYSIOLOGY-LONDON, 2020, 598 (18): : 3911 - 3925
  • [9] Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT2A receptors
    Chunyan Chen
    Xinyuan Han
    Fenling Fan
    Ya Liu
    Tingzhong Wang
    Juanjuan Wang
    Peijing Hu
    Aiqun Ma
    Hongyan Tian
    Molecular and Cellular Biochemistry, 2014, 397 : 267 - 276
  • [10] Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT2A receptors
    Chen, Chunyan
    Han, Xinyuan
    Fan, Fenling
    Liu, Ya
    Wang, Tingzhong
    Wang, Juanjuan
    Hu, Peijing
    Ma, Aiqun
    Tian, Hongyan
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 397 (1-2) : 267 - 276
1234