MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

被引：0

作者：

Zeng, Zhihong ^{[1
]}

Wang, Rui-Yu ^{[1
]}

Shi, Yuexi ^{[1
]}

Qiu, Yihua ^{[1
]}

Mak, Duncan H. ^{[2
]}

Coombes, Kevin ^{[3
]}

Yoo, Suk Young ^{[1
]}

Jessen, Katti ^{[4
]}

Liu, Yi ^{[5
]}

Rommel, Christian ^{[6
]}

Kantarjian, Hagop M. ^{[1
]}

Kornblau, Steven M. ^{[1
]}

Fruman, David ^{[7
]}

Andreeff, Michael ^{[1
]}

Konopleva, Marina ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Sect Mol Hematol & Therapy, Houston, TX 77030 USA

[3] Ohio State Univ, Columbus, OH 43210 USA

[4] eFFECTOR Therapeut, San Diego, CA USA

[5] Wellspring Biosci, San Diego, CA USA

[6] 5Amgen Inc, Thousand Oaks, CA USA

[7] UC Irvine, Irvine, CA USA

来源：

BLOOD | 2014年 / 124卷 / 21期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 20 条

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[12] Synergistic anti-cancer activity of CDK4/6 inhibitor palbociclib and dual mTOR kinase inhibitor MLN0128 in pRb-expressing ER-negative breast cancer
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[13] AMG925, a Dual FLT3-CDK4/6 Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML Progenitor/Stem Cells
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[20] The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
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