Biodegradable nanofiber-based piezoelectric transducer

被引:216
作者
Curry, Eli J. [1 ]
Le, Thinh T. [2 ]
Das, Ritopa [1 ]
Ke, Kai [3 ]
Santorella, Elise M. [4 ]
Paul, Debayon [4 ]
Chorsi, Meysam T. [2 ]
Tran, Khanh T. M. [1 ]
Baroody, Jeffrey [1 ]
Borges, Emily R. [1 ]
Ko, Brian [5 ]
Golabchi, Asiyeh [6 ]
Xin, Xiaonan [7 ]
Rowe, David [7 ]
Yue, Lixia [8 ]
Feng, Jianlin [8 ]
Morales-Acosta, M. Daniela [9 ]
Wu, Qian [10 ]
Chen, I-Ping [11 ]
Cui, X. Tracy [6 ]
Pachter, Joel [4 ]
Nguyen, Thanh D. [1 ,2 ,9 ]
机构
[1] Univ Connecticut, Dept Biomed Engn, Storrs, CT 06269 USA
[2] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA
[3] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Sichuan, Peoples R China
[4] Univ Connecticut, Hlth Ctr, Dept Immunol, Blood Brain Barrier Lab, Farmington, CT 06030 USA
[5] Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA
[6] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15260 USA
[7] Univ Connecticut, Hlth Ctr, Ctr Regenerat Med & Skeletal Dev, Farmington, CT 06030 USA
[8] Univ Connecticut, Hlth Ctr, Dept Cell Biol, Farmington, CT 06030 USA
[9] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA
[10] Univ Connecticut, Hlth Ctr, Pathol & Lab Med, Farmington, CT 06030 USA
[11] Univ Connecticut, Hlth Ctr, Sch Dent Med, Dept Oral Hlth & Diagnost Sci, Farmington, CT 06030 USA
关键词
biodegradable; piezoelectric; PLLA; pressure sensors; ultrasound transducer; FOCUSED ULTRASOUND; BLOOD; BRAIN; MOLYBDENUM; DELIVERY; PLA;
D O I
10.1073/pnas.1910343117
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Piezoelectric materials, a type of "smart" material that generates electricity while deforming and vice versa, have been used extensively for many important implantable medical devices such as sensors, transducers, and actuators. However, commonly utilized piezoelectric materials are either toxic or nondegradable. Thus, implanted devices employing these materials raise a significant concern in terms of safety issues and often require an invasive removal surgery, which can damage directly interfaced tissues/organs. Here, we present a strategy for materials processing, device assembly, and electronic integration to 1) create biodegradable and biocompatible piezoelectric PLLA [poly(L-lactic acid)] nanofibers with a highly controllable, efficient, and stable piezoelectric performance, and 2) demonstrate device applications of this nanomaterial, including a highly sensitive biodegradable pressure sensor for monitoring vital physiological pressures and a biodegradable ultrasonic transducer for blood-brain barrier opening that can be used to facilitate the delivery of drugs into the brain. These significant applications, which have not been achieved so far by conventional piezoelectric materials and bulk piezoelectric PLLA, demonstrate the PLLA nanofibers as a powerful material platform that offers a profound impact on various medical fields including drug delivery, tissue engineering, and implanted medical devices.
引用
收藏
页码:214 / 220
页数:7
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