Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition

被引：8
作者：
Tan, Sherilyn [1 ,2 ]
Porter, Tenielle [3 ,4 ,5 ]
Bucks, Romola S. [2 ]
Weinborn, Michael [1 ,2 ]
Milicic, Lidija [3 ,4 ]
Brown, Ailsa [3 ]
Rainey-Smith, Stephanie R. [1 ,2 ,6 ]
Taddei, Kevin [1 ,6 ]
Ames, David [7 ,8 ,9 ]
Masters, Colin L. [7 ,10 ]
Maruff, Paul [7 ,15 ]
Savage, Greg [14 ]
Rowe, Christopher C. [7 ,11 ,12 ]
Villemagne, Victor L. [4 ,7 ,11 ,12 ]
Brown, Belinda [1 ,4 ,13 ]
Sohrabi, Hamid R. [1 ,6 ,13 ,14 ]
Laws, Simon M. [3 ,4 ,5 ]
Martins, Ralph N. [1 ,6 ,10 ,14 ]
机构：
[1] Australian Alzheimers Res Fdn, Ralph & Patricia Sarich Neurosci Res Inst, Nedlands, WA, Australia
[2] Univ Western Australia, Sch Psychol Sci, Nedlands, WA, Australia
[3] Edith Cowan Univ, Sch Med & Hlth Sci, Collaborat Genom & Translat Grp, Joondalup, WA, Australia
[4] Edith Cowan Univ, Ctr Precis Hlth, Joondalup, WA, Australia
[5] Curtin Univ, Fac Hlth Sci, Sch Pharm & Biomed Sci, Curtin Hlth Innovat Res Inst, Bentley, WA, Australia
[6] Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Med & Hlth Sci, Joondalup, WA, Australia
[7] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia
[8] Univ Melbourne, Acad Unit Psychiat Old Age, Parkville, Vic, Australia
[9] Natl Ageing Res Inst NARI, Parkville, Vic, Australia
[10] Cooperat Res Ctr Mental Hlth, Carlton, Vic, Australia
[11] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia
[12] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia
[13] Murdoch Univ, Coll Sci Engn & Educ SHEE, Ctr Hlth Ageing, Murdoch, WA, Australia
[14] Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia
[15] CogState Ltd, Melbourne, Vic, Australia
来源：
HORMONES AND BEHAVIOR | 2021年 / 131卷
关键词：
Testosterone; Androgen receptor; Cognition; Attention; Processing speed; Language; Executive function; Memory; OLDER MEN; ELDERLY-MEN; ALZHEIMERS-DISEASE; BONE METABOLISM; SEX-HORMONES; RISK-FACTOR; POLYMORPHISM; GENE; AGE; HEALTH;
D O I：
10.1016/j.yhbeh.2021.104966
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Age-related decrease in testosterone levels is a potential risk factor for cognitive decline in older men. However, observational studies and clinical trials have reported inconsistent results on the effects of testosterone on individual cognitive domains. Null findings may be attributed to factors that studies have yet to consider. In particular, individual variations in polyglutamine (CAG) length in the androgen receptor (AR) gene could alter androgenic activity in brain regions associated with cognitive processes including memory and executive functions. However, the role of AR CAG repeat length as a moderator of the relationship between testosterone levels and cognition has not been investigated. Therefore, we aimed to examine the relationship between baseline calculated free testosterone (cFT) levels, change in cFT levels over 18 months and CAG repeat length on cognitive performance in memory, executive function, language, attention and processing speed domains. These relationships were examined in 304 cognitively normal older male participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing. In the attention and processing speed domain, a short CAG repeat length appears to exacerbate the effects of low baseline cFT levels that are also lower than expected at follow-up. These results highlight that individual variations in AR CAG repeat length should be considered in future studies and clinical trials that examine the complex relationship between testosterone and cognition.
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页数：10
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