Renal cell carcinoma in acquired cystic kidney disease: Volume growth rate determined by helical computed tomography

被引:16
作者
Takebayashi, S
Hidai, H
Chiba, T
Irisawa, M
Matsubara, S
机构
[1] Yokohama City Univ, Med Ctr, Dept Radiol, Minami Ku, Yokohama, Kanagawa 232, Japan
[2] Yokohama Daiichi Hosp, Dept Urol, Yokohama, Kanagawa, Japan
[3] Yokohama Daiichi Hosp, Dept Radiol, Yokohama, Kanagawa, Japan
关键词
renal cell carcinoma; hemodialysis (HD); helical computed tomography (CT); tumor growth;
D O I
10.1053/ajkd.2000.17656
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The aim of this study is to determine the growth rate and behavior of renal cell carcinoma in chronic hemodialysis patients with acquired cystic kidney disease (ACKD), Renal cell carcinomas in 17 hemodialysis patients (mean age, 52 +/- 11 years; mean hemodialysis duration, 7.2 +/- 3.3 years) with ACKD were examined with helical computed tomography (CT) for 0.5 to 6.0 years (mean, 2.1 +/- 1.9 years). The 17 renal cell carcinomas were histologically proven and graded after nephrectomy (16 patients) or autopsy (1 patient). Tumor volume was estimated by counting the number of pixels in the tumor and a 1-cm(2) area on helical computed tomographic scan using a personal computer. Estimated volume growth rates and doubling times of the carcinoma were correlated with histological grades. Fifteen of the 17 neoplasms (88%) were less than 3 cm in diameter at initial CT. The overall volume growth rate was 0.07 to 17.34 cm(3)/y (mean, 4.14 +/- 5.66 cm(3)/y), and the estimated volume-doubling time was 0.08 to 23.31 years (mean, 5.09 +/- 6.99 years). The mean growth rate of the 3 grade 3 carcinomas was 6.01 +/- 4.50 cm(3)/y (range, 0.88 to 9.28 cm(3)/y), which was significantly greater than that of the 9 grade 1 carcinomas (0.40 +/- 0.40 cm(3)/y; range, 0.09 to 1.37 cm(3)/y) or the 5 grade 2 tumors (0.79 +/- 0.74 cm(3)/y; range, 0.12 to 2.00 cm(3)/y). Eleven of the 17 carcinomas (65%) had more than a 1-year volume-doubling time. The 3 grade 3 neoplasms and 1 of the grade 2 lesions had less than a 0.5-year doubling time. (C) 2000 by the National Kidney Foundation, Inc.
引用
收藏
页码:759 / 766
页数:8
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