Novel SWCNTs-mesoporous silicon nanocomposite as efficient non-enzymatic glucose biosensor

The development and designing of self-testing blood-glucose electrochemical biosensor is an effective approach for diabetic patients to overcome and control this high health concerning issue. Herein, we successfully designed novel single-walled carbon nanotubes-porous silicon nanocomposites framework (SWCNTs-PSi NCs) via simple stain etching and ultrasonication techniques. X-ray Diffraction (XRD), Raman spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Energy-Dispersive Spectroscopy (EDS), and X-ray Photoelectron Spectroscopy (XPS) were employed to study the porous morphology with similar to 30 nm pore size and overall structural characterization of the SWCNTs-PSi NCs. This newly fabricated SWCNTs-PSi modified glassy carbon electrode (GCE) biosensor can measure an extremely wide range of glucose (0.5-28.5 mM) in phosphate buffer solution (PBS) compared to the regular glucose concentration level in human blood serum (3.9-7.1 mM) with a sensitivity 0.0614 mu AmM-1 cm(-2) and detection limit 9.6 +/- 0.1 mu M. This non-enzymatic glucose biosensor demonstrated excellent selectivity during the investigation of the possible impact of common interfering substances that are present in human blood. This proposed non-enzymatic glucose biosensor has also been tested for real human blood serum analysis to determine blood glucose levels showing highly motivated results. The newly designed SWCNTs-PSi/GCE biosensor exhibits excellent reproducibility and repeatability, along with long-term stability.