Field and geochemical observations of the granitoids of the Homrit Waggat area in the central Eastern Desert of Egypt reveal two magmatic phases. The early phase of weakly deformed subduction-related calc-alkaline rocks includes tonalite and granodiorite. We name the later phase the Homrit Waggat Pluton (HWP); it includes undeformed syenogranite, alkali feldspar granite, and minor albitized granite. The tonalite and granodiorite have distinct negative Nb-Ta anomalies and lower alkalis, REE, Nb, Zr, and Hf than the HWP. The early magmatic pulse is a subduction-related suite, likely generated by underplating of mantle-derived magmas that triggered partial melting of mafic lower crust; mixing of these melts led to intermediate magma that further fractionated to tonalite and granodiorite. The HWP granites of the late magmatic pulse are transitional from a subduction-related to an anorogenic within-plate environment, plausibly generated by post-collisional lithosphere delamination. Although the parent magma of the HWP was I-type, extensive fractional crystallization produced residual liquids with A(2)-type character. Albitized granites are found only along the outer margin of the HWP, and contacts with the alkali feldspar granite are gradational, suggesting fluid interactions at a late stage of crystallization. The original textures of the albitized granites are preserved, but their bulk composition was modified by the production of Na-rich minerals and the removal of K, REE, and some trace elements by fluids.