A probabilistic view of immunology: Drawing parallels with physics

被引：13

作者：

Hodgkin, Philip D. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2007年 / 85卷 / 04期

关键词：

immune regulation; molecular determinism; stochastic processes; immunological theory;

D O I：

10.1038/sj.icb.7100061

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating 'machines', taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of the dynamic multifaceted immune system appears immensely complicated. In this article I contrast two alternative frameworks, the deterministic and the probabilistic as competing paths to achieve successful quantitative immune models. As the two alternatives are traditional scientific rivals, I use the probabilistic fields in physics to highlight the potential value of the probabilistic perspective in immunology.

引用

页码：295 / 299

页数：5

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