Editorial: Computational and Experimental Approaches in Multi-target Pharmacology

被引:8
作者
Anastasio, Thomas J. [1 ]
机构
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Mol & Integrat Physiol, Computat Neurobiol Lab, Urbana, IL 61801 USA
关键词
polypharmacy; drug combination; drug repurposing; synergy; systems biology; multifactorial process; computer modeling; high throughput screening; ALZHEIMERS-DISEASE; DRUG DISCOVERY; POLYPHARMACOLOGY; THERAPEUTICS; SYSTEMS;
D O I
10.3389/fphar.2017.00443
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页数:3
相关论文
共 12 条
[1]   Exploring the contribution of estrogen to amyloid-beta regulation: a novel multifactorial computational modeling approach [J].
Anastasio, Thomas J. .
FRONTIERS IN PHARMACOLOGY, 2013, 4
[2]   A critical analysis of the 'amyloid cascade hypothesis' [J].
Armstrong, Richard A. .
FOLIA NEUROPATHOLOGICA, 2014, 52 (03) :211-225
[3]   Multi-Target-Directed Ligands in Alzheimer's Disease Treatment [J].
Bajda, M. ;
Guzior, N. ;
Ignasik, M. ;
Malawska, B. .
CURRENT MEDICINAL CHEMISTRY, 2011, 18 (32) :4949-4975
[4]  
Boran ADW, 2010, CURR OPIN DRUG DISC, V13, P297
[5]   Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives [J].
Bulusu, Krishna C. ;
Guha, Rajarshi ;
Mason, Daniel J. ;
Lewis, Richard P. I. ;
Muratov, Eugene ;
Motamedi, Yasaman Kalantar ;
Cokol, Murat ;
Bender, Andreas .
DRUG DISCOVERY TODAY, 2016, 21 (02) :225-238
[6]   The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics [J].
Carmo Carreiras, M. ;
Mendes, Eduarda ;
Jesus Perry, M. ;
Francisco, Ana Paula ;
Marco-Contelles, J. .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (15) :1745-1770
[7]   Network-Based Strategies Can Help Mono-and Poly-pharmacology Drug Discovery: A Systems Biology View [J].
Engin, H. Billur ;
Gursoy, Attila ;
Nussinov, Ruth ;
Keskin, Ozlem .
CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (08) :1201-1207
[8]   Pathways to Alzheimer's disease [J].
Hardy, J. ;
Bogdanovic, N. ;
Winblad, B. ;
Portelius, E. ;
Andreasen, N. ;
Cedazo-Minguez, A. ;
Zetterberg, H. .
JOURNAL OF INTERNAL MEDICINE, 2014, 275 (03) :296-303
[9]   Multicomponent therapeutics for networked systems [J].
Keith, CT ;
Borisy, AA ;
Stockwell, BR .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (01) :71-U10
[10]   A Step Further Towards Multitarget Drugs for Alzheimer and Neuronal Vascular Diseases: Targeting the Cholinergic System, Amyloid-β Aggregation and Ca2+ Dyshomeostasis [J].
Leon, R. ;
Marco-Contelles, J. .
CURRENT MEDICINAL CHEMISTRY, 2011, 18 (04) :552-576