Male fertility in relapsing-remitting multiple sclerosis patients treated with natalizumab and ocrelizumab: A prospective case-control study

被引：10
作者：
D'Amico, Emanuele [1 ]
Zanghi, Aurora [1 ]
Calogero, Aldo Eugenio [2 ]
Patti, Francesco [1 ]
机构：
[1] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Via Santa Sofia 78, I-95123 Catania, Italy
[2] Univ Catania, Dept Clin & Expt Med, Catania, Italy
来源：
MULTIPLE SCLEROSIS JOURNAL | 2021年 / 27卷 / 14期
关键词：
Multiple sclerosis; men fertility; gonadal steroids; ocrelizumab; natalizumab; SEMEN QUALITY; PREGNANCY; WOMEN;
D O I：
10.1177/13524585211009208
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Scarce data are available about the impact of natalizumab (NTZ) and ocrelizumab (OCR) on male fertility in relapsing-remitting multiple sclerosis (RRMS). In this case-control prospective study, the gonadal steroids and the sperm parameters have been analysed at the time of the RRMS diagnosis and after 12 months from the beginning of the investigated therapies. Sixteen men with RRMS and sixteen matched healthy controls were included. At enrolment and after 12 months on therapy, the gonadal steroids and the sperm parameters of men with RRMS did not differ from the healthy controls. In conclusion, therapy with NTZ and OCR had no impact on fertility status in our cohort of men with RRMS. Further randomized and prospective studies are needed.
引用
收藏
页码：2284 / 2287
页数：4
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