Cryptotomography: Reconstructing 3D Fourier Intensities from Randomly Oriented Single-Shot Diffraction Patterns

被引：83

作者：

Loh, N. D. ^{[1
]}

Bogan, M. J. ^{[2
]}

Elser, V. ^{[1
]}

Barty, A.

Boutet, S. ^{[2
]}

Bajt, S.

Hajdu, J. ^{[4
]}

Ekeberg, T. ^{[4
]}

Maia, F. R. N. C. ^{[4
]}

Schulz, J.

Seibert, M. M. ^{[4
]}

Iwan, B. ^{[4
]}

Timneanu, N. ^{[4
]}

Marchesini, S. ^{[5
]}

Schlichting, I. ^{[3
,6
]}

Shoeman, R. L. ^{[3
,6
]}

Lomb, L. ^{[3
,6
]}

Frank, M. ^{[7
]}

Liang, M.

Chapman, H. N. ^{[8
]}

机构：

[1] Cornell Univ, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

[2] SLAC Natl Accelerator Lab, Menlo Pk, CA 94025 USA

[3] DESY, Ctr Free Electron Laser Sci, Max Planck Adv Study Grp, D-22607 Hamburg, Germany

[4] Uppsala Univ, Dept Cell & Mol Biol, Lab Mol Biophys, SE-75124 Uppsala, Sweden

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

[6] Max Planck Inst Med Res, D-69120 Heidelberg, Germany

[7] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA

[8] Univ Hamburg, D-22761 Hamburg, Germany

来源：

PHYSICAL REVIEW LETTERS | 2010年 / 104卷 / 22期

基金：

瑞典研究理事会;

关键词：

FREE-ELECTRON LASER;

D O I：

10.1103/PhysRevLett.104.225501

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We reconstructed the 3D Fourier intensity distribution of monodisperse prolate nanoparticles using single-shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast x-ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the expansion-maximization-compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single-shot diffraction imaging of single biomolecules.

引用

页数：5

共 13 条

[1] Camera for coherent diffractive imaging and holography with a soft-x-ray free-electron laser
Bajt, Sasa
Chapman, Henry N.
Spiller, Eberhard A.
Alameda, Jennifer B.
Woods, Bruce W.
Frank, Matthias
Bogan, Michael J.
Barty, Anton
Boutet, Sebastien
Marchesini, Stefano
Hau-Riege, Stefan P.
Hajdu, Janos
Shapiro, David
[J]. APPLIED OPTICS, 2008, 47 (10) : 1673 - 1683
[2] Non-destructive characterization and alignment of aerodynamically focused particle beams using single particle charge detection
Benner, W. Henry
Bogan, Michael J.
Rohner, Urs
Boutet, Sebastien
Woods, Bruce
Frank, Matthias
[J]. JOURNAL OF AEROSOL SCIENCE, 2008, 39 (11) : 917 - 928
[3] Aerosol Imaging with a Soft X-Ray Free Electron Laser
Bogan, Michael J.
Boutet, Sebastien
Chapman, Henry N.
Marchesini, Stefano
Barty, Anton
Benner, W. Henry
Rohner, Urs
Frank, Matthias
Hau-Riege, Stefan P.
Bajt, Sasa
Woods, Bruce
Seibert, M. Marvin
Iwan, Bianca
Timneanu, Nicusor
Hajdu, Janos
Schulz, Joachim
[J]. AEROSOL SCIENCE AND TECHNOLOGY, 2010, 44 (03) : I - VI
[4] BOGAN MJ, UNPUB
[5] Characteristics of focused soft X-ray free-electron laser beam determined by ablation of organic molecular solids
Chalupsky, J.
Juha, L.
Kuba, J.
Cihelka, J.
Hajkova, V.
Koptyaev, S.
Krasa, J.
Velyhan, A.
Bergh, M.
Caleman, C.
Hajdu, J.
Bionta, R. M.
Chapman, H.
Hau-Riege, S. P.
London, R. A.
Jurek, M.
Krzywinski, J.
Nietubyc, R.
Pelka, J. B.
Sobierajski, R.
Meyer-ter-Vehn, J.
Tronnier, A.
Sokolowski-Tinten, K.
Stojanovic, N.
Tiedtke, K.
Toleikis, S.
Tschentscher, T.
Wabnitz, H.
Zastrau, U.
[J]. OPTICS EXPRESS, 2007, 15 (10) : 6036 - 6043
[6] Femtosecond diffractive imaging with a soft-X-ray free-electron laser
Chapman, Henry N.
Barty, Anton
Bogan, Michael J.
Boutet, Sebastien
Frank, Matthias
Hau-Riege, Stefan P.
Marchesini, Stefano
Woods, Bruce W.
Bajt, Sasa
Benner, Henry
London, Richard A.
Ploenjes, Elke
Kuhlmann, Marion
Treusch, Rolf
Duesterer, Stefan
Tschentscher, Thomas
Schneider, Jochen R.
Spiller, Eberhard
Moeller, Thomas
Bostedt, Christoph
Hoener, Matthias
Shapiro, David A.
Hodgson, Keith O.
Van der Spoel, David
Burmeister, Florian
Bergh, Magnus
Caleman, Carl
Huldt, Goesta
Seibert, M. Marvin
Maia, Filipe R. N. C.
Lee, Richard W.
Szoeke, Abraham
Timneanu, Nicusor
Hajdu, Janos
[J]. NATURE PHYSICS, 2006, 2 (12) : 839 - 843
[7] High-resolution ab initio three-dimensional x-ray diffraction microscopy
Chapman, HN
Barty, A
Marchesini, S
Noy, A
Hau-Riege, SR
Cui, C
Howells, MR
Rosen, R
He, H
Spence, JCH
Weierstall, U
Beetz, T
Jacobsen, C
Shapiro, D
[J]. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2006, 23 (05) : 1179 - 1200
[8] MAXIMUM LIKELIHOOD FROM INCOMPLETE DATA VIA EM ALGORITHM
DEMPSTER, AP
LAIRD, NM
RUBIN, DB
[J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL, 1977, 39 (01): : 1 - 38
[9] Noise Limits on Reconstructing Diffraction Signals From Random Tomographs
Elser, Veit
[J]. IEEE TRANSACTIONS ON INFORMATION THEORY, 2009, 55 (10) : 4715 - 4722
[10] Structure from fleeting illumination of faint spinning objects in flight
Fung, Russell
Shneerson, Valentin
Saldin, Dilano K.
Ourmazd, Abbas
[J]. NATURE PHYSICS, 2009, 5 (01) : 64 - 67

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