Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

被引：153

作者：

Collins, Nicholas ^{[1
]}

Jiang, Xiaodong ^{[2
,3
]}

Zaid, Ali ^{[1
]}

Macleod, Bethany L. ^{[1
]}

Li, Jane ^{[1
]}

Park, Chang Ook ^{[2
,3
]}

Haque, Ashraful ^{[4
,5
]}

Bedoui, Sammy ^{[1
]}

Heath, William R. ^{[1
]}

Mueller, Scott N. ^{[1
]}

Kupper, Thomas S. ^{[2
,3
]}

Gebhardt, Thomas ^{[1
]}

Carbone, Francis R. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3000, Australia

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Dermatol, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Harvard Skin Dis Res Ctr, Boston, MA 02115 USA

[4] Univ Queensland, Malaria Immunol Lab, QIMR Berghofer Med Res Inst, Herston, Qld 4006, Australia

[5] Univ Queensland, Australian Infect Dis Res Ctr, Herston, Qld 4006, Australia

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

DENDRITIC CELLS; RESIDENT; TISSUE; INFECTION; LYMPHOCYTE; ACTIVATION; IMMUNITY; SUBSETS; VIRUS;

D O I：

10.1038/ncomms11514

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4(+) T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4(+) T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4(+) T-cell recruitment. Skin CCL5 is derived from CD11b(+) cells and CD8(+) T cells, with the elimination of the latter decreasing CD4(+) T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4(+) memory T cells in skin, which is altered by infection and inflammation history.

引用

页数：13

共 41 条

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