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Surface-Enhanced Raman Spectroscopy Study of 4-ATP on Gold Nanoparticles for Basal Cell Carcinoma Fingerprint Detection
被引:22
作者:
Luu Manh Quynh
[1
]
Nguyen Hoang Nam
[1
,2
]
Kong, K.
[3
]
Nguyen Thi Nhung
[1
]
Notingher, I.
[3
]
Henini, M.
[3
]
Nguyen Hoang Luong
[2
]
机构:
[1] Vietnam Natl Univ, Hanoi Univ Sci, Fac Phys, 334 Nguyen Trai, Hanoi, Vietnam
[2] Vietnam Natl Univ, Hanoi Univ Sci, Nano & Energy Ctr, Hanoi, Vietnam
[3] Univ Nottingham, Sch Phys & Astron, Univ Pk, Nottingham NG7 2RD, England
基金:
美国国家卫生研究院;
关键词:
Skin cancer;
basal cell carcinoma;
surface-enhanced Raman scattering;
gold nanoparticles;
SCATTERING;
SILVER;
ASSEMBLIES;
SURGERY;
TISSUE;
SERS;
D O I:
10.1007/s11664-016-4421-9
中图分类号:
TM [电工技术];
TN [电子技术、通信技术];
学科分类号:
0808 ;
0809 ;
摘要:
The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm(-1) corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm(-1) band to detect the distribution of 4-ATP-coated gold nanoparticles attached to skin tissue ex vivo.
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页码:2563 / 2568
页数:6
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