Urocortin-like immunoreactivity in the substantia nigra, ventral tegmental area and Edinger-Westphal nucleus of rat

被引：62
作者：
Yamamoto, H [1 ]
Maeda, T
Fujimura, M
Fujimiya, M
机构：
[1] Shiga Univ Med Sci, Dept Anat, Shiga 52021, Japan
[2] Shiga Univ Med Sci, Dept Surg 2, Shiga 52021, Japan
来源：
NEUROSCIENCE LETTERS | 1998年 / 243卷 / 1-3期
关键词：
immunohistochemistry; urocortin; substantia nigra; ventral tegmental area; gold-labeled WGAapoHRP (WGAapoHRP-Au); tyrosine hydroxylase; rat;
D O I：
10.1016/S0304-3940(98)00071-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurons showing intense urocortin-like immunoreactivity (Ucn-IR) were found immunohistochemically in the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA), as well as in Edinger-Westphal nucleus (E-W), in the rat brain. Almost all Ucn-immunoreactive neuronal cell bodies in the SNc and VTA showed immunoreactivity for tyrosine hydroxylase. Injection of a retrograde tracer, colloidal gold-labeled WGAapoHRP, into the cervical spinal cord resulted in labeling of some E-W neurons with Ucn-IR. These findings suggest that Ucn is located in the cell bodies of dopaminergic neurons, as well as in the cell bodies of E-W neurons sending axons to the spinal cord. (C) 1998 Elsevier Science Ireland Ltd.
引用
收藏
页码：21 / 24
页数：4
相关论文
共 13 条
  • [1] WHEAT-GERM AGGLUTININ-APOHRP GOLD - A NEW RETROGRADE TRACER FOR LIGHT-MICROSCOPIC AND ELECTRON-MICROSCOPIC SINGLE-LABEL AND DOUBLE-LABEL STUDIES
    BASBAUM, AI
    MENETREY, D
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 261 (02) : 306 - 318
  • [2] EDINGER-WESTPHAL NUCLEUS - CELLS THAT PROJECT TO SPINAL-CORD CONTAIN CORTICOTROPIN-RELEASING FACTOR
    CHUNG, RY
    MASON, P
    STRASSMAN, A
    MACIEWICZ, R
    [J]. NEUROSCIENCE LETTERS, 1987, 83 (1-2) : 13 - 19
  • [3] Increase of urocortin-like immunoreactivity in the rat hypothalamo-neurohypophysial system after salt loading and hypophysectomy
    Hara, Y
    Ueta, Y
    Isse, T
    Kabashima, N
    Shibuya, I
    Hattori, Y
    Yamashita, H
    [J]. NEUROSCIENCE LETTERS, 1997, 227 (02) : 127 - 130
  • [4] HARA Y, 1997, NEUROSCI LETT, V229, P6568
  • [5] KALIVAS PW, 1987, J PHARMACOL EXP THER, V242, P757
  • [6] CLONING AND CHARACTERIZATION OF A FUNCTIONALLY DISTINCT CORTICOTROPIN-RELEASING FACTOR-RECEPTOR SUBTYPE FROM RAT-BRAIN
    LOVENBERG, TW
    LIAW, CW
    GRIGORIADIS, DE
    CLEVENGER, W
    CHALMERS, DT
    DESOUZA, EB
    OLTERSDORF, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) : 836 - 840
  • [7] Urocortin, a novel neuropeptide with anxiogenic-like properties
    Moreau, JL
    Kilpatrick, G
    Jenck, F
    [J]. NEUROREPORT, 1997, 8 (07) : 1697 - 1701
  • [8] Cardiac inotropic actions of urocortin in conscious sheep
    Parkes, DG
    Vaughan, J
    Rivier, J
    Vale, W
    May, CN
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1997, 272 (05): : H2115 - H2122
  • [9] DIRECT HYPOTHALAMO-AUTONOMIC CONNECTIONS
    SAPER, CB
    LOEWY, AD
    SWANSON, LW
    COWAN, WM
    [J]. BRAIN RESEARCH, 1976, 117 (02) : 305 - 312
  • [10] Appetite-suppressing effects of urocortin, a CRF-related neuropeptide
    Spina, M
    MerloPich, E
    Chan, RKW
    Basso, AM
    Rivier, J
    Vale, W
    Koob, GF
    [J]. SCIENCE, 1996, 273 (5281) : 1561 - 1564
12