Chromeno[2,3-d]pyrimidine-triones Synthesis by a Three-Component Coupling Reaction

被引：26
作者：
Ghahremanzadeh, Ramin [1 ,2 ]
Fereshtehnejad, Fatemeh [1 ]
Bazgir, Ayoob [1 ]
机构：
[1] Shahid Beheshti Univ, Dept Chem, Tehran 1983963113, Iran
[2] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran 196151177, Iran
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 04期
关键词：
chromeno[2,3-d]pyrimidine; cyclohexane-1,3-dione; barbituric acid; aldehyde; ONE-POT SYNTHESIS; IMMUNODEFICIENCY-VIRUS TYPE-1; EFFICIENT SYNTHESIS; DERIVATIVES; MICROWAVE; AGENTS; CYCLIZATION;
D O I：
10.1248/cpb.58.516
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A simple and one-pot synthesis of new chromeno[2,3-d]pyrimidine-triones by a three-component condensation reaction of barbituric acids, aldehydes and cyclohexane-1,3-diones in refluxing ethanol in the presence of p-toluenesulfonic acid (p-TSA) for 3-10 h is reported. Two cyclohexane-1,3-diones, four barbituric acids and six substituted aldehydes were chosen for the library validation. Prominent among the advantages of this new method are operational simplicity, good yields and easy work-up procedures employed.
引用
收藏
页码：516 / 520
页数：5
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