Resveratrol Enhances Mitomycin C-mediated Suppression of Human Colorectal Cancer Cell Proliferation by Up-regulation of p21WAF1/CIP1

被引：1
作者：
Ali, Irshad [1 ]
Braun, Donald P. [1 ]
机构：
[1] Canc Treatment Ctr Amer, Midwestern Reg Med Ctr, Zion, IL 60099 USA
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 10期
关键词：
p21(WAF1/CIP1); resveratrol; mitomycin C; colorectal cancer; cell cycle; PERITONEAL CARCINOMATOSIS; BREAST-CANCER; APOPTOSIS; CYCLE; THERAPY; TARGETS; P53; BIOAVAILABILITY; CHEMOTHERAPY; ABSORPTION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Ann: Studies have shown that natural products could potentially be employed in combination therapies to decrease toxicity to healthy tissues by chemotherapy drugs. No studies however, have investigated the potential modulatory role of resveratrol (RV) on mitomycin C (MMC)-mediated effects on colorectal cancer. The aim of the present study was to investigate the impact of RV on iVIMC-mediated inhibition cancer cell proliferation and to assess the potential mechanisms for such effects. Materials and Methods: Primary cell lines generated from resected colorectal tumor specimens were treated with RV, MiVIC or RV+MiVIC and cell proliferation and gene expression analyses were performed. Results: Suppression of cell proliferation by.RV+MMC was significantly greater than individual treatments. RV+MMC synergistically modulated several genes but the up-regulation of p21(WAF1/CIP1) was several-fold greater. Conclusion: The up-regulation of p21(WAF1/CIP1) which inhibits the cell cycle at G(0)/G(1) and phases, may represent the predominant mechanism for enhancement of MMC-mediated anti-cancer effects by resveratrol.
引用
收藏
页码：5439 / 5446
页数：8
相关论文
共 35 条
[1]   p21 in cancer: intricate networks and multiple activities [J].
Abbas, Tarek ;
Dutta, Anindya .
NATURE REVIEWS CANCER, 2009, 9 (06) :400-414
[2]   Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma [J].
Aboumarzouk, Omar M. ;
Somani, Bhaskar ;
Ahmad, Sarfraz ;
Nabi, Ghulam ;
Townell, Nicholas ;
Kata, Slawomir G. .
UROLOGY ANNALS, 2013, 5 (03) :184-189
[3]  
Aggarwal BB, 2004, ANTICANCER RES, V24, P2783
[4]   Mitomycin C for the treatment of pharyngoesophageal stricture after total laryngopharyngectomy and microvascular free tissue reconstruction [J].
Annino, DJ ;
Goguen, LA .
LARYNGOSCOPE, 2003, 113 (09) :1499-1502
[5]   Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms [J].
Athar, Mohammad ;
Back, Jung Ho ;
Kopelovich, Levy ;
Bickers, David R. ;
Kim, Arianna L. .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2009, 486 (02) :95-102
[6]  
Beaujard AC, 2000, CANCER-AM CANCER SOC, V88, P2512, DOI 10.1002/1097-0142(20000601)88:11<2512::AID-CNCR12>3.0.CO
[7]  
2-J
[8]   A phase II study of mitomycin C and oral etoposide for advanced adenocarcinoma of the upper gastrointestinal tract [J].
Braybrooke, JP ;
OByrne, KJ ;
Saunders, MP ;
Propper, DJ ;
Boardman, P ;
Taylor, M ;
Ganesan, TS ;
Talbot, C ;
Harris, AL .
ANNALS OF ONCOLOGY, 1997, 8 (03) :294-296
[9]   Resveratrol and cancer: focus on in vivo evidence [J].
Carter, Lindsay G. ;
D'Orazio, John A. ;
Pearson, Kevin J. .
ENDOCRINE-RELATED CANCER, 2014, 21 (03) :R209-R225
[10]   Mitomycin in Anal Cancer: Still the Standard of Care [J].
Chin, Joanna Y. ;
Hong, Theodore S. ;
Ryan, David P. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (35) :4297-4301
1234