Do we really care about incidental lung nodules? - Review of atypical lung carcinoid and a proposal for systematic patient follow up

被引:7
作者
Motiwala, Henal [1 ]
Bansal, Itisha [2 ]
Goyal, Pradeep [3 ]
Dorokhova, Olena [4 ]
Kumar, Yogesh [5 ]
Olsavsky, Thomas D. [6 ]
DiMeo, Albert [7 ]
Gupta, Nishant [3 ]
机构
[1] Quinnipiac Univ, Frank H Netter MD Sch Med, N Haven, CT USA
[2] New York Presbyterian Brooklyn Methodist Hosp, Dept Anesthesiol, Brooklyn, NY USA
[3] St Vincents Med Ctr, Dept Radiol, 2800 Main St, Bridgeport, CT 06606 USA
[4] St Vincents Med Ctr, Dept Pathol, Bridgeport, CT USA
[5] Bridgeport Hosp, Yale New Haven Heath, Dept Radiol, Bridgeport, CT USA
[6] St Vincents Med Ctr, Dept Nucl Med & Thorac Radiol, Bridgeport, CT USA
[7] St Francis Hosp, Dept Cardiovasc Surg, Roslyn, NY USA
关键词
Solitary pulmonary nodule; atypical carcinoids (ACs); lung carcinoids; neuroendocrine tumors (NETs); DIFFERENTIATED-NEUROENDOCRINE-TUMORS; MANAGEMENT; DIAGNOSIS; CHALLENGES;
D O I
10.21037/tlcr.2017.05.05
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Atypical lung carcinoids are intermediate-grade neuroendocrine tumors (NETs) with malignant potential. They are often detected incidentally on imaging done for non-related causes, as the patients are frequently asymptomatic. Histopathology is required to confirm the diagnosis with immunohistochemistry (IHC). Due to their indolent nature, these are often diagnosed only in the advanced stages. Treatment options include chemoradiation for widespread disease versus surgery for local or minimally invasive disease. This article describes a nonsmoker female with enlarging solitary pulmonary nodule who was initially lost to follow up, subsequently operated and with final pathology revealing atypical lung carcinoid. This case stress on the schematic follow up of these incidentally detected pulmonary nodules. Inspired from the mandatory lay mammography report letters recommended by ACR, this article proposes sending lay letters to patients for pulmonary nodule follow up, directly from the Radiology Department to reinforce the importance of timely follow up, which will complement the information provided to the patient from their primary care physician or pulmonologist's office.
引用
收藏
页码:387 / 392
页数:6
相关论文
共 14 条
[1]  
Blagev Denitza P, 2016, J Am Coll Radiol, V13, pR18, DOI 10.1016/j.jacr.2015.12.008
[2]   Clinical Presentation and Evaluation of Neuroendocrine Tumors of the Lung [J].
Detterbeck, Frank C. .
THORACIC SURGERY CLINICS, 2014, 24 (03) :267-+
[3]   Ways to Improve Radiologists' Adherence to Fleischner Society Guidelines for Management of Pulmonary Nodules [J].
Eisenberg, Ronald L. .
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY, 2013, 10 (06) :439-441
[4]   Multidisciplinary management of advanced lung neuroendocrine tumors [J].
Filosso, Pier Luigi ;
Ferolla, Piero ;
Guerrera, Francesco ;
Ruffini, Enrico ;
Travis, William D. ;
Rossi, Giulio ;
Lausi, Paolo Olivo ;
Oliaro, Alberto .
JOURNAL OF THORACIC DISEASE, 2015, 7 :S163-S171
[5]   Lung neuroendocrine tumor (NET) patient (pt)-reported experience: Results from the first global NET pt surveyA collaboration between the international neuroendocrine cancer alliance (INCA) and Novartis pharmaceuticals. [J].
Granberg, Dan ;
Sissons, Maia ;
Kolarova, Teodora ;
Goldstein, Grace ;
Leyden, John .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
[6]   Bronchopulmonary neuroendocrine tumors [J].
Gustafsson, Bjorn I. ;
Kidd, Mark ;
Chan, Anthony ;
Malfertheiner, Max V. ;
Modlin, Irvin M. .
CANCER, 2008, 113 (01) :5-21
[7]   Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease [J].
Hendifar, Andrew E. ;
Marchevsky, Alberto M. ;
Tuli, Richard .
JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (03) :425-436
[8]   Current understanding and approach to well differentiated lung neuroendocrine tumors: an update on classification and management [J].
Hilal, Talal .
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2017, 9 (03) :189-199
[9]   Neuroendocrine Tumors of the Bronchopulmonary System (Typical and Atypical Carcinoid Tumors): Current Strategies in Diagnosis and Treatment. Conclusions of an Expert Meeting February 2011 in Weimar, Germany [J].
Hoersch, Dieter ;
Schmid, Kurt W. ;
Anlauf, Martin ;
Darwiche, Kaid ;
Denecke, Tim ;
Baum, Richard P. ;
Spitzweg, Christine ;
Grohe, Christian ;
Presselt, Norbert ;
Stremmel, Christian ;
Heigener, David F. ;
Serke, Monika ;
Kegel, Thomas ;
Pavel, Marianne ;
Waller, Cornelius F. ;
Deppermann, Karl-Matthias ;
Arnold, Rudolf ;
Huber, Rudolf M. ;
Weber, Matthias M. ;
Hoffmann, Hans .
ONCOLOGY RESEARCH AND TREATMENT, 2014, 37 (05) :266-+
[10]   Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide [J].
Kulke, Matthew H. ;
O'Dorisio, Thomas ;
Phan, Alexandria ;
Bergsland, Emily ;
Law, Linda ;
Banks, Phillip ;
Freiman, Joel ;
Frazier, Kenny ;
Jackson, Jessica ;
Yao, James C. ;
Kvols, Larry ;
Lapuerta, Pablo ;
Zambrowicz, Brian ;
Fleming, Douglas ;
Sands, Arthur .
ENDOCRINE-RELATED CANCER, 2014, 21 (05) :705-714