Constitutively Active Akt Contributes to Vincristine Resistance in Human Retinoblastoma Cells

被引：12
作者：
Zhang, Hao [1 ]
Li, Bin [1 ]
Bai, Shu-wei [1 ]
Wang, Hui-juan [1 ]
机构：
[1] Capital Med Univ, Beijing Tong Ren Hosp, Beijing Tong Ren Eye Ctr, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Drug resistance; Akt; Vincristine; P-glycoprotein; Retinoblastoma; P-GLYCOPROTEIN EXPRESSION; OVARIAN-CANCER CELLS; MULTIDRUG-RESISTANCE; PI3K/AKT PATHWAY; CHEMOTHERAPY; APOPTOSIS; CHEMORESISTANCE; ACTIVATION; MECHANISMS; INHIBITOR;
D O I：
10.3109/07357900903179641
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Akt mediates survival signals which preserve various cancer cells from apoptosis. Its correlation with chemoresistance of cancer cells has attracted much attention. But how Akt affects vincristine-induced cell death in retinoblastoma is unknown. Here we show that Akt activity is involved in vincristine-induced cytotoxicity in retinoblastoma SO-Rb50 cells. Inhibition of Akt can decrease the survival of both sensitive and vincristine-resistant SO-Rb50 cells and increase the sensitivity of both cell lines to vincristine by enhancing the cell apoptosis and increasing the cellular accumulation of the drug. Akt may be a target for reducing drug resistance that improves the treatment for retinoblastoma.
引用
收藏
页码：156 / 165
页数：10
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