Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2

被引：78

作者：

Au, Lewis ^{[1
,2
,3
]}

Fendler, Annika ^{[1
]}

Shepherd, Scott T. C. ^{[1
,2
,3
]}

Rzeniewicz, Karolina ^{[1
]}

Cerrone, Maddalena ^{[4
,5
]}

Byrne, Fiona ^{[1
]}

Carlyle, Eleanor ^{[2
,3
]}

Edmonds, Kim ^{[2
,3
]}

Del Rosario, Lyra ^{[2
,3
]}

Shon, John ^{[6
]}

Haynes, Winston A. ^{[6
]}

Ward, Barry ^{[1
]}

Shum, Ben ^{[1
,2
,3
]}

Gordon, William ^{[1
]}

Gerard, Camille L. ^{[1
,7
]}

Xie, Wenyi ^{[1
]}

Joharatnam-Hogan, Nalinie ^{[2
,3
]}

Young, Kate ^{[2
,3
]}

Pickering, Lisa ^{[2
,3
]}

Furness, Andrew J. S. ^{[2
,3
]}

Larkin, James ^{[2
,3
]}

Harvey, Ruth ^{[8
]}

Kassiotis, George ^{[9
]}

Gandhi, Sonia ^{[10
,11
]}

Swanton, Charles ^{[12
]}

Fribbens, Charlotte ^{[12
,13
,14
]}

Wilkinson, Katalin A. ^{[4
]}

Wilkinson, Robert J. ^{[4
,5
]}

Lau, David K. ^{[14
]}

Banerjee, Susana ^{[15
,16
]}

Starling, Naureen ^{[14
]}

Chau, Ian ^{[14
]}

Turajlic, Samra ^{[1
,2
,3
]}

机构：

[1] Francis Crick Inst, Canc Dynam Lab, London, England

[2] Royal Marsden NHS Fdn Trust, Skin Unit, London, England

[3] Royal Marsden NHS Fdn Trust, Renal Unit, London, England

[4] Francis Crick Inst, TB Lab, London, England

[5] Imperial Coll London, Dept Infect Dis, London, England

[6] Serimmune Inc, Goleta, CA USA

[7] Lausanne Univ Hosp CHUV, Precis Oncol Ctr, Lausanne, Switzerland

[8] Francis Crick Inst, Worldwide Influenza Ctr, London, England

[9] Francis Crick Inst, Retroviral Immunol Lab, London, England

[10] Francis Crick Inst, Neurodegenerat Biol Lab, London, England

[11] UCL Queen Sq Inst Neurol, Queen Sq, London, England

[12] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England

[13] Royal Marsden NHS Fdn Trust, Acute Oncol Serv, London, England

[14] Royal Marsden NHS Fdn Trust, Gastrointestinal & Lymphoma Unit, Sutton, Surrey, England

[15] Royal Marsden NHS Fdn Trust, Gynaecol Unit, London, England

[16] Inst Canc Res, London, England

来源：

NATURE MEDICINE | 2021年 / 27卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

RESPONSES; COVID-19; SAFETY;

D O I：

10.1038/s41591-021-01387-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rare case of cytokine release syndrome in a patient on anti-PD-1 blockade that was likely related to BNT162b2 vaccination supports prospective monitoring of patients with cancer after COVID-19 vaccine administration. Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an extremely rare immune-related adverse event of immune checkpoint inhibitors. We present a case of CRS that occurred 5 d after vaccination with BTN162b2 (tozinameran)-the Pfizer-BioNTech mRNA COVID-19 vaccine-in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-gamma/IL-2R/IL-18/IL-16/IL-10) and steroid responsiveness. The close temporal association of vaccination and diagnosis of CRS in this case suggests that CRS was a vaccine-related adverse event; with anti-PD1 blockade as a potential contributor. Overall, further prospective pharmacovigillence data are needed in patients with cancer, but the benefit-risk profile remains strongly in favor of COVID-19 vaccination in this population.

引用

页码：1362 / +

页数：11

共 26 条

[1] Cancer, COVID-19, and Antiviral Immunity: The CAPTURE Study [J].

Au, Lewis ;

Boos, Laura Amanda ;

Swerdlow, Anthony ;

Byrne, Fiona ;

Shepherd, Scott T. C. ;

Fendler, Annika ;

Turajlic, Samra .

CELL, 2020, 183 (01) :4-10

[2] The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution [J].

Ballhausen, Alexej ;

Przybilla, Moritz Jakob ;

Jendrusch, Michael ;

Haupt, Saskia ;

Pfaffendorf, Elisabeth ;

Seidler, Florian ;

Witt, Johannes ;

Hernandez Sanchez, Alejandro ;

Urban, Katharina ;

Draxlbauer, Markus ;

Krausert, Sonja ;

Ahadova, Aysel ;

Kalteis, Martin Simon ;

Pfuderer, Pauline L. ;

Heid, Daniel ;

Stichel, Damian ;

Gebert, Johannes ;

Bonsack, Maria ;

Schott, Sarah ;

Blaeker, Hendrik ;

Seppala, Toni ;

Mecklin, Jukka-Pekka ;

Ten Broeke, Sanne ;

Nielsen, Maartje ;

Heuveline, Vincent ;

Krzykalla, Julia ;

Benner, Axel ;

Riemer, Angelika Beate ;

von Knebel Doeberitz, Magnus ;

Kloor, Matthias .

NATURE COMMUNICATIONS, 2020, 11 (01)

[3] Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates [J].

Brahmer, Julie R. ;

Drake, Charles G. ;

Wollner, Ira ;

Powderly, John D. ;

Picus, Joel ;

Sharfman, William H. ;

Stankevich, Elizabeth ;

Pons, Alice ;

Salay, Theresa M. ;

McMiller, Tracee L. ;

Gilson, Marta M. ;

Wang, Changyu ;

Selby, Mark ;

Taube, Janis M. ;

Anders, Robert ;

Chen, Lieping ;

Korman, Alan J. ;

Pardoll, Drew M. ;

Lowy, Israel ;

Topalian, Suzanne L. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (19) :3167-3175

[4] Immune Checkpoint Inhibitor-Related Cytokine Release Syndrome: Analysis of WHO Global Pharmacovigilance Database [J].

Ceschi, Alessandro ;

Noseda, Roberta ;

Palin, Karine ;

Verhamme, Katia .

FRONTIERS IN PHARMACOLOGY, 2020, 11

[5] Clinical determinants for fatality of 44,672 patients with COVID-19 [J].

Deng, Guangtong ;

Yin, Mingzhu ;

Chen, Xiang ;

Zeng, Furong .

CRITICAL CARE, 2020, 24 (01)

[6] COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials [J].

Desai, Aakash ;

Gainor, Justin F. ;

Hegde, Aparna ;

Schram, Alison M. ;

Curigiliano, Guiseppe ;

Pal, Sumanta ;

Liu, Stephen V. ;

Halmos, Balazs ;

Groisberg, Roman ;

Grande, Enrique ;

Dragovich, Tomislav ;

Matrana, Marc ;

Agarwal, Neeraj ;

Chawla, Sant ;

Kato, Shumei ;

Morgan, Gilberto ;

Kasi, Pashtoon M. ;

Solomon, Benjamin ;

Loong, Herbert H. ;

Park, Haeseong ;

Choueiri, Toni K. ;

Subbiah, Ishwaria M. ;

Pemmaraju, Naveen ;

Subbiah, Vivek .

NATURE REVIEWS CLINICAL ONCOLOGY, 2021, 18 (05) :313-319

[7] Cytokine Storm [J].

Fajgenbaum, David C. ;

June, Carl H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2255-2273

[8] Human memory T cells: generation, compartmentalization and homeostasis [J].

Farber, Donna L. ;

Yudanin, Naomi A. ;

Restifo, Nicholas P. .

NATURE REVIEWS IMMUNOLOGY, 2014, 14 (01) :24-35

[9]

Haynes, 2020, HIGH RESOLUTION MAPP, DOI [10.1101/2020.11.23.20235002v1.full, DOI 10.1101/2020.11.23.20235002V1.FULL]

[10] Fulminant Myocarditis with Combination Immune Checkpoint Blockade [J].

Johnson, Douglas B. dbj ;

Balko, Justin M. jmb ;

Compton, Margaret L. mlc ;

Chalkias, Spyridon sc ;

Gorham, Joshua jc ;

Xu, Yaomin yx ;

Hicks, Mellissa mh ;

Puzanov, Igor ip ;

Alexander, Matthew R. mra ;

Bloomer, Tyler L. tlb ;

Becker, Jason R. jrb ;

Slosky, David A. das ;

Phillips, Elizabeth J. ejp ;

Pilkinton, Mark A. map ;

Craig-Owens, Laura lco ;

Kola, Nina nk ;

Plautz, Gregory gp ;

Reshef, Daniel S. dsr ;

Deutsch, Jonathan S. jsd ;

Deering, Raquel P. rpd ;

Olenchock, Benjamin A. bao ;

Lichtman, Andrew H. ahl ;

Roden, Dan M. dmr ;

Seidman, Christine E. ces ;

Koralnik, Igor J. ijk ;

Seidman, Jonathan G. jgs ;

Hoffman, Robert D. rdh ;

Taube, Janis M. jmt ;

Diaz, Luis A. Jr lad ;

Anders, Robert A. raa ;

Sosman, Jeffrey A. jas ;

Moslehi, Javid J. jjm .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (18) :1749-1755

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