Devising a best practice approach to prophylaxis in boys with severe haemophilia: evaluation of current treatment strategies

被引：14
作者：
Carcao, M. [1 ]
Chambost, H. [2 ]
Ljung, R. [3 ]
机构：
[1] Hosp Sick Children, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada
[2] Univ Mediterranee, Hop Enfants La Timone, Serv Hematol Pediat, Marseille, France
[3] Malmo Univ Hosp, Dept Paediat & Coagulat Disorders, Malmo, Sweden
来源：
HAEMOPHILIA | 2010年 / 16卷
关键词：
haemophilia; prophylaxis; protocol; replacement factor; PREVIOUSLY UNTREATED PATIENTS; INHIBITOR DEVELOPMENT; FACTOR-VIII; IMMUNE TOLERANCE; RISK-FACTORS; CHILDREN; MANAGEMENT; THERAPY; CARE;
D O I：
10.1111/j.1365-2516.2009.02196.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Data from prospective studies clearly demonstrate the efficacy of prophylactic treatment of haemophilia in reducing joint- or life-threatening bleeding and the associated consequences for quality of life. Debate remains, however, regarding the optimal implementation of prophylaxis. Our aim in this review was to identify a best practice approach to factor replacement prophylaxis in boys with haemophilia. We evaluate prophylactic treatment regimens currently used in Swedish, Canadian and French centres and highlight key issues, including the optimal age for starting prophylaxis, the optimal treatment dosage/schedule and patient compliance.
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收藏
页码：4 / 9
页数：6
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