The HIV-1 Tat Team Gets Bigger

被引：2
|
作者：
Rice, Andrew P. [1 ]
机构：
[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
来源：
CELL HOST & MICROBE | 2010年 / 7卷 / 03期
关键词：
TRANSACTIVATION; TRANSCRIPTION; METHYLATION; ELONGATION;
D O I：
10.1016/j.chom.2010.03.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.
引用
收藏
页码：179 / 181
页数：3
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