The HIV-1 Tat Team Gets Bigger

被引：2
|
作者：
Rice, Andrew P. [1 ]
机构：
[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
来源：
CELL HOST & MICROBE | 2010年 / 7卷 / 03期
关键词：
TRANSACTIVATION; TRANSCRIPTION; METHYLATION; ELONGATION;
D O I：
10.1016/j.chom.2010.03.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.
引用
收藏
页码：179 / 181
页数：3
相关论文
共 50 条
  • [31] Proteomic characterization of HIV-1 Tat interactome
    VW Gautier
    N O'Donohu
    S Pennington
    WW Hall
    Retrovirology, 3 (Suppl 1)
  • [32] Tat basic domain: A "Swiss army knife" of HIV-1 Tat?
    Kurnaeva, Margarita A.
    Sheval, Eugene V.
    Musinova, Yana R.
    Vassetzky, Yegor S.
    REVIEWS IN MEDICAL VIROLOGY, 2019, 29 (02)
  • [33] HIV-1 tat intersects the SUMO pathway to regulate HIV-1 promoter activity
    McCartin, Ann Marie
    Kulkarni, Anurag
    Le Douce, Valentin
    Gautier, Virginie
    RETROVIROLOGY, 2016, 13
  • [34] The HIV-1 Tat Protein: Mechanism of Action and Target for HIV-1 Cure Strategies
    Rice, Andrew P.
    CURRENT PHARMACEUTICAL DESIGN, 2017, 23 (28) : 4098 - 4102
  • [35] Mechanism of internalization of HIV-1 Tat and Tat-fusion proteins
    Fittipaldi, A
    Ferrari, A
    Arcangeli, C
    Monica, M
    Pellegrini, V
    Beltram, F
    Giacca, M
    MOLECULAR THERAPY, 2003, 7 (05) : S372 - S372
  • [36] Tat-SF1: Cofactor for stimulation of transcriptional elongation by HIV-1 Tat
    Zhou, QA
    Sharp, PA
    SCIENCE, 1996, 274 (5287) : 605 - 610
  • [37] Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat
    Ghezzi, S
    Noonan, DM
    Aluigi, MG
    Vallanti, G
    Cota, M
    Benelli, R
    Morini, M
    Reeves, JD
    Vicenzi, E
    Poli, G
    Albini, A
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 270 (03) : 992 - 996
  • [38] HIV-1 Tat is present in the serum of people living with HIV-1 despite viral suppression
    Shmakova, Anna
    Tsimailo, Ivan
    Kozhevnikova, Yana
    Gerard, Laurence
    Boutboul, David
    Oksenhendler, Eric
    Tuaillon, Edouard
    Rivault, Aurelie
    Germini, Diego
    Vassetzky, Yegor
    Beaumelle, Bruno
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2024, 142
  • [39] Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency
    Jean, Maxime Junior
    Power, Derek
    Kong, Weili
    Huang, Huachao
    Santoso, Netty
    Zhu, Jian
    VIRUSES-BASEL, 2017, 9 (04):
  • [40] HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription
    Andrey Ivanov
    Xionghao Lin
    Tatiana Ammosova
    Andrey V. Ilatovskiy
    Namita Kumari
    Hatajai Lassiter
    Nowah Afangbedji
    Xiaomei Niu
    Michael G. Petukhov
    Sergei Nekhai
    Retrovirology, 15
12345