The HIV-1 Tat Team Gets Bigger

被引：2

作者：

Rice, Andrew P. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

CELL HOST & MICROBE | 2010年 / 7卷 / 03期

关键词：

TRANSACTIVATION; TRANSCRIPTION; METHYLATION; ELONGATION;

D O I：

10.1016/j.chom.2010.03.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.

引用

页码：179 / 181

页数：3

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