The HIV-1 Tat Team Gets Bigger

被引：2
|
作者：
Rice, Andrew P. [1 ]
机构：
[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
来源：
CELL HOST & MICROBE | 2010年 / 7卷 / 03期
关键词：
TRANSACTIVATION; TRANSCRIPTION; METHYLATION; ELONGATION;
D O I：
10.1016/j.chom.2010.03.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.
引用
收藏
页码：179 / 181
页数：3
相关论文
共 50 条
  • [21] The expression of HIV-1 tat in Lactococcus lactis
    Selvam, Deepak
    D'silva, Anish
    Panchapakesan, Arun
    Gohil, Yuvrajsinh
    Singh, Jayendra
    Hanna, Luke Elizabeth
    Ranga, Udaykumar
    PROTEIN EXPRESSION AND PURIFICATION, 2024, 217
  • [22] HIV-1 tat and T cell apoptosis
    Krammer, Peter H.
    RETROVIROLOGY, 2006, 3
  • [23] Molecular dynamics simulations on HIV-1 Tat
    Pantano, S
    Tyagi, M
    Giacca, M
    Carloni, P
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2004, 33 (04): : 344 - 351
  • [24] HIV-1 Tat: Role in Bystander Toxicity
    Ajasin, David
    Eugenin, Eliseo A.
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10
  • [25] Proteomic characterization of HIV-1 tat interactome
    Gautier, V. W.
    O'Donohu, N.
    Pennington, S.
    Hall, W. W.
    RETROVIROLOGY, 2006, 3
  • [26] RNA recognition by HIV-1 Tat and Rev
    Tan, RY
    Brodsky, A
    Williamson, JR
    Frankel, AD
    SEMINARS IN VIROLOGY, 1997, 8 (03): : 186 - 193
  • [27] TRANSACTIVATION OF HETEROLOGOUS PROMOTERS BY HIV-1 TAT
    HAN, P
    BROWN, R
    BARSOUM, J
    NUCLEIC ACIDS RESEARCH, 1991, 19 (25) : 7225 - 7229
  • [28] STRUCTURAL STUDIES OF HIV-1 TAT PROTEIN
    BAYER, P
    KRAFT, M
    EJCHART, A
    WESTENDORP, M
    FRANK, R
    ROSCH, P
    JOURNAL OF MOLECULAR BIOLOGY, 1995, 247 (04) : 529 - 535
  • [29] Comparative analysis of HIV-1 Tat variants
    Pantano, S
    Carloni, P
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 58 (03) : 638 - 643
  • [30] Effects of HIV-1 Tat on Enteric Neuropathogenesis
    Ngwainmbi, Joy
    De, Dipanjana D.
    Smith, Tricia H.
    El-Hage, Nazira
    Fitting, Sylvia
    Kang, Minho
    Dewey, William L.
    Hauser, Kurt F.
    Akbarali, Hamid I.
    JOURNAL OF NEUROSCIENCE, 2014, 34 (43): : 14243 - 14251
12345