N'-(1-([1,1'-biphenyl]-4-yl)ethylidene)-2-cyanoacetohydrazide as scaffold for the synthesis of diverse heterocyclic compounds as prospective antitumor and antimicrobial activities

被引:18
作者
Hamed, Nancy A. [1 ]
Marzouk, Magda I. [1 ]
Ismail, Mahmoud F. [1 ]
Hekal, Mohamed H. [1 ]
机构
[1] Ain Shams Univ, Dept Chem, Fac Sci, Khalifa El Maamon St,Abbasiya Sq, Cairo 11566, Egypt
关键词
4-acetyl biphenyl; antimicrobial activity; antitumor activity; cyanoacetamide derivative; cyanoacetohydrazide; POLYBROMINATED DIPHENYL ETHERS; RAPID COLORIMETRIC ASSAY; ORGANOCHLORINE PESTICIDES; POLYCHLORINATED-BIPHENYLS; DERIVATIVES; ANTIOXIDANT; SURVIVAL; GROWTH;
D O I
10.1080/00397911.2019.1655578
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In this article, the main target was to study the antitumor and antimicrobial efficacy of new heterocycles conjugated with biphenyl moiety in-vitro. This was implemented by utilizing N'-(1-([1,1'-biphenyl]-4-yl)ethylidene)-2-cyanoacetohydrazide 3 as a material for the synthesis of various heterocyclic compounds. Among of them, some compounds were selected and assayed against two antitumor cell lines as (HepG2) and (HCT-116). Conspicuously, the achieved results showed that compounds 6, 13, and 23 possess significant potency against both cancer cell lines. Particularly, compound 13 exhibited a remarkable efficacy, similar to the standard anticancer drug (doxorubicin), against both cancer cell lines. Noteworthy, compound 13 may serve as a potential anticancer therapeutic drug in the future. On the other hand, In-vitro antifungal and antibacterial activities of selected compounds were assayed and the results indicated that the compound 6 exhibited significant potency against Candida albicans, while compounds 6 and 8 displayed spectacular results for the antibacterial study.
引用
收藏
页码:3017 / 3029
页数:13
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