Clinicopathological features and differential diagnosis of primary bilateral seminal vesicle mucinous carcinoma

Objective: To explore clinical features, imageological examination and differential diagnosis of primary bilateral seminal vesicle carcinoma. Methods Analyzed clinical features, pathological features immunophenotype of 1 case of primary bilateral seminal vesicle mucinous carcinoma. Results: Male patient, aged 51, accompanied with hematospermia, dysuria, but without gross hematuria. PSA was not high, CEA, CA19-9 and CA724 increased, postoperative 3 indicators dropped to normal range. Under microscope, seen a lot of mucus, mucous cells floating or covering inner walls. Cells with severe atypia. MRI showed bilateral seminal vesicles cystic lesions. Substantially bilateral seminal vesicles increased, cystic section, sallow solid areas, yellowish jelly material in capsule. Immunophenotype: CK7 and CA125 of tumor cell were positive, CK20 were focally positive, PSA and CEA were negative. Followed up for 6 months without recurrence and metastasis. Conclusions Primary bilateral seminal vesicle carcinoma is very rare. Differential diagnosis required that it is diagnosed with mucinous carcinoma of adjacent organs. Comprehensive inspection and immunohistochemistry are helpful to the correct diagnosis.