Two new sesquiterpenes from Alisma orientalis

被引：28

作者：

Jiang, Zhi-Yong

Zhang, Xue-Mei

Zhou, Jun

Zhang, Feng-Xue

Chen, Ji-Jun ^{[1
]}

Lue, Yang

Wu, Li

Zheng, Qi-Tai

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Yunnan, Peoples R China

[3] Guangzhou Univ Chinese Tradit Med, Inst Trop Med Sci, Guangzhou 510405, Guangdong, Peoples R China

[4] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 06期

关键词：

Alisma orientalis; sesquiterpenoid; alismorientol A; alismorientol B; anti-hepatitis B virus activity;

D O I：

10.1248/cpb.55.905

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new sesquiterpenoids named alismorientols A (1) and B (2) were isolated from the rhizomes of Alisma orientalis collected in Sichuan province, People's Republic of China. Their structures were elucidated based on spectroscopic analyses (1D and 2D NMR data including HSQC, HMBC, COSY, and ROESY) and X-ray crystallographic analysis. Anti-hepatitis B virus (HBV) bioassay revealed that compound I showed moderate anti-HBV activity in vitro with IC50 for HBsAg: 1.1,mu M, for HBeAg: 14.7 mu M.

引用

页码：905 / 907

页数：3

共 6 条

[1] A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis [J].

Jiang, Zhi-Yong ;

Zhang, Xue-Mei ;

Zhang, Feng-Xue ;

Liu, Ni ;

Zhao, Fang ;

Zhou, Jun ;

Chen, Ji-Jun .

PLANTA MEDICA, 2006, 72 (10) :951-954

[2]

LU Y, 1992, CHINESE CHEM LETT, V3, P637

[3]

OSHOMA Y, 1983, PHYTOCHEMISTRY, V22, P183

[4] Guaiane-type sesquiterpenoids from Alisma orientalis [J].

Peng, GP ;

Tian, G ;

Huang, XF ;

Lou, FC .

PHYTOCHEMISTRY, 2003, 63 (08) :877-881

[5]

YOSHIKAWA M, 1992, CHEM PHARM BULL, V40, P2582, DOI 10.1248/cpb.40.2582

[6]

1977, DICT CHINESE CRUDE D, P1461

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