Isolation, structure elucidation and biological activity of 8-O-methylaverufin and 1,8-O-dimethylaverantin as new antifungal agents from Penicillium chrysogenum

被引：20
作者：
Maskey, RP [1 ]
Grün-Wollny, I [1 ]
Laatsch, H [1 ]
机构：
[1] Univ Gottingen, Dept Organ Chem, D-37077 Gottingen, Germany
来源：
JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 05期
关键词：
D O I：
10.7164/antibiotics.56.459
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the screening of fungi for bioactive components, 8-0-methylaverufin (1b) and 1,8-O-dimethylaverantin (2b) were isolated from the culture broth of Penicillium chrysogenum. The structure of these new antibiotics were determined by interpretation of the 1D and 2D NMR spectra and by comparison of the NMR data with those of the structurally related averufin (la) and averantin (2a). Both compounds have moderate antifungal activity.
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页码：459 / 463
页数：5
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