Potential of microneedles in enhancing delivery of photosensitising agents for photodynamic therapy

被引：35

作者：

Kearney, Mary-Carmel ^{[1
]}

Brown, Sarah ^{[1
]}

McCrudden, Maeliosa T. C. ^{[1
]}

Brady, Aaron J. ^{[1
]}

Donnelly, Ryan F. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2014年 / 11卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

Photodynamic therapy; Microneedle; Photosensitiser; Preformed photosensitisers; 5-AMINOLEVULINIC ACID; METHYL; 5-AMINOLEVULINATE; POLYMER MICRONEEDLES; INTRADERMAL DELIVERY; PROTOPORPHYRIN-IX; ACTINIC KERATOSES; BOWENS-DISEASE; ARRAYS; ALA; AMINOLEVULINATE;

D O I：

10.1016/j.pdpdt.2014.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy can be used in the treatment of pre-malignant and malignant diseases. It offers advantages over other therapies currently used in the treatment of skin lesions including avoidance of damage to surrounding tissue and minimal or no scarring. Unfortunately, systemic delivery of photosensitising agents can result in adverse effects, such as prolonged cutaneous photosensitivity; while topical administration lacks efficacy in the clearance of deeper skin lesions and those with a thick overlying keratotic layer. Therefore, enhancement of conventional photosensitiser delivery is desired. However, the physicochemical properties of photosensitising agents, such as extreme hydrophilicity or lipophilicity and large molecular weights make this challenging. This paper reviews the potential of microneedles as a viable method to overcome these delivery-limiting physicochemical characteristics and discusses the current benefits and limitations of solid, dissolving and hydrogel-forming microneedles. Clinical studies in which microneedles have successfully improved photodynamic therapy are also discussed, along with benefits which microneedles offer, such as precise photosensitiser localisation, painless application and reduction in waiting times between photosensitiser administration and irradiation highlighted. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：459 / 466

页数：8

共 56 条

[1] Micro-scale devices for transdermal drug delivery [J].