Targeting Malassezia species for Novel Synthetic and Natural Antidandruff Agents

被引：31

作者：

Angiolella, Letizia ^{[1
]}

Carradori, Simone ^{[2
]}

Maccallini, Cristina ^{[2
]}

Giusiano, Gustavo ^{[3
]}

Supuran, Claudiu T. ^{[4
]}

机构：

[1] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Ple Moro 5, I-00185 Rome, Italy

[2] G dAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy

[3] Univ Nacl Nordeste, CONICET, Fac Med, Dept Micol,Inst Med Reg, Resistencia, Argentina

[4] Univ Firenze, Sect Pharmaceut & Nutriceut Sci, Neurofarba Dept, Via U Schiff 6, I-50019 Florence, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2017年 / 24卷 / 22期

关键词：

Azoles; carbonic anhydrase inhibitors; dandruff; lipase inhibitors; Malassezia spp; natural inhibitors; BETA-CARBONIC ANHYDRASE; IN-VITRO SUSCEPTIBILITY; BROTH MICRODILUTION METHOD; SEBORRHEIC DERMATITIS; SELECTIVE INHIBITORS; ANTI-DANDRUFF; BIOLOGICAL EVALUATION; SILVER NANOPARTICLES; ANTIFUNGAL AGENTS; ATOPIC-DERMATITIS;

D O I：

10.2174/0929867324666170404110631

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malassezia spp. are lipophilic yeasts not only present in the normal skin micro-flora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. These drawbacks have prompted the research toward novel synthetic and natural derivatives/nanomaterials targeting other pivotal enzymes/pathways such as carbonic anhydrase (MgCA) and lipases, alone or in combination, in order to improve the eradication rate of this fungus. This review accomplished an update on this important topic dealing with the latest discoveries of synthetic scaffolds and natural products for the treatment of Malassezia spp.-related diseases, thus suggesting new opportunities to design innovative and alternative anti-dandruff drugs.

引用

页码：2392 / 2412

页数：21

共 110 条

[1] Active antifungal substances from natural sources [J].

Abad, Maria Jose ;

Ansuategui, Maria ;

Bermejo, Paulina .

ARKIVOC, 2007, :116-145

[2]

Ahn KJ, 1998, KOREAN J MED MYCOL, V3, P81

[3] Increased hydrophobicity in Malassezia species correlates with increased proinflammatory cytokine expression in human keratinocytes [J].

Akaza, Narifumi ;

Akamatsu, Hirohiko ;

Takeoka, Shiori ;

Mizutani, Hiroshi ;

Nakata, Satoru ;

Matsunaga, Kayoko .

MEDICAL MYCOLOGY, 2012, 50 (08) :802-810

[4] Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme [J].

Akdemir, Atilla ;

De Monte, Celeste ;

Carradori, Simone ;

Supuran, Claudiu T. .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2015, 30 (01) :114-118

[5] Malassezia pachydermatis fungemia in a preterm neonate resistant to fluconazole and flucytosine [J].

Al-Sweih, Noura ;

Ahmad, Suhail ;

Joseph, Leena ;

Khan, Seema ;

Khan, Ziauddin .

MEDICAL MYCOLOGY CASE REPORTS, 2014, 5 :9-11

[6]

Allen HB., 2015, J CLIN EXP DERMATOL, V6, P6

[7] In Vitro Amphotericin B Susceptibility of Malassezia pachydermatis Determined by the CLSI Broth Microdilution Method and Etest Using Lipid-Enriched Media [J].

Alvarez-Perez, Sergio ;

Blanco, Jose L. ;

Pelaez, Teresa ;

Cutuli, Maite ;

Garcia, Marta E. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (07) :4203-4206

[8]

Angiolella L., 2017, MED MYCOL, DOI [10.1093/mmy/myx014, DOI 10.1093/MMY/MYX014.]

[9] Size- and shape-dependent clinical and mycological efficacy of silver nanoparticles on dandruff [J].

Anwar, Mohammad F. ;

Yadav, Deepak ;

Jain, Swati ;

Kapoor, Sumeet ;

Rastogi, Shweta ;

Arora, Indu ;

Samim, Mohammed .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 11 :147-161

[10] ESCMID† and ECMM‡ joint clinical guidelines for the diagnosis and management of rare invasive yeast infections [J].

Arendrup, M. C. ;

Boekhout, T. ;

Akova, M. ;

Meis, J. F. ;

Cornely, O. A. ;

Lortholary, O. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 :76-98

← 1 2 3 4 5 6 7 8 9 10 →