Term delivery in a woman with severe congenital neutropenia, treated with growth colony stimulating factor

被引:16
作者
Kaufmann, SJ [1 ]
Sharif, K
Sharma, V
McVerry, BA
机构
[1] St James Univ Hosp, Assisted Concept Unit, Leeds LS9 7TF, W Yorkshire, England
[2] St James Univ Hosp, Dept Haematol, Leeds LS9 7TF, W Yorkshire, England
[3] Birmingham Maternity Hosp, Acad Dept Obstet & Gynaecol, Birmingham B15 2TG, W Midlands, England
关键词
congenital neutropenia; growth colony stimulating factor; pregnancy;
D O I
10.1093/humrep/13.2.498
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The patient was diagnosed in childhood as having severe congenital neutropenia and had recurrent admissions with severe infections, In 1987, prior to getting married, she was sterilized, She continued to require i.v. antibiotics when she contracted a severe infection, On one occasion, she was treated with growth colony stimulating factor (G-CSF), Her increased neutrophil count was sustained following this treatment, In June 1993, she wished to start a family and underwent in-vitro fertilization (IVF) treatment. G-CSF was given prior to oocyte retrieval, She conceived on her first cycle and an ultrasound scan revealed a singleton pregnancy, Throughout the course of the pregnancy, her white cell count was monitored closely and remained at <1.0x10(9)/I, The pregnancy progressed uneventfully and at 37 weeks gestation she was admitted for G-CSF injections, At 38 weeks she was delivered of a boy weighing 3350 g, by elective Caesarean section, His white cell count was normal, This is the first case of G-CSF being used before conception and during pregnancy in a patient with congenital neutropenia, It shows that advances in cytokine therapy and close interdisciplinary liaison can lead to a successful outcome and help patients, who would otherwise remain childless, to achieve a family.
引用
收藏
页码:498 / 499
页数:2
相关论文
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[3]  
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