Automated parallel synthesis of chalcone-based screening libraries

被引：165

作者：

Powers, DG ^{[1
]}

Casebier, DS ^{[1
]}

Fokas, D ^{[1
]}

Ryan, WJ ^{[1
]}

Troth, JR ^{[1
]}

Coffen, DL ^{[1
]}

机构：

[1] ArQule Inc, Medford, MA 02155 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(98)00137-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using a variety of condensation and cyclization reactions, nine combinatorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 mu M quantities. The ease with which a broad range of diversity can be fabricated around a single molecular motif using automated parallel solution phase synthesis has been demonstrated. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4085 / 4096

页数：12

共 10 条

[1] NON-DECARBOXYLATIVE 1,3-DIPOLAR CYCLOADDITIONS OF IMINES OF ALPHA-AMINO-ACIDS AS A ROUTE TO PROLINE DERIVATIVES [J].