Diabetes and risk of incident cancer: a large population-based cohort study in Israel

被引:104
作者
Chodick, Gabriel [1 ,2 ]
Heymann, Anthony D. [1 ,2 ]
Rosenmann, Lena [1 ,2 ]
Green, Manfred S. [3 ]
Flash, Shira [1 ,2 ]
Porath, Avi [1 ]
Kokia, Ehud [1 ,2 ]
Shalev, Varda [1 ,2 ]
机构
[1] Maccabi Healthcare Serv, Div Med, IL-68125 Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] Univ Haifa, Sch Publ Hlth, IL-31999 Haifa, Israel
关键词
Cohort studies; Colonic neoplasms; Diabetes mellitus; Pancreatic neoplasms; Genital organs neoplasms; RENAL-CELL CARCINOMA; COLORECTAL-CANCER; PANCREATIC-CANCER; GALLBLADDER CANCER; MEDICAL CONDITIONS; PROSTATE-CANCER; BREAST-CANCER; BODY-SIZE; FOLLOW-UP; MELLITUS;
D O I
10.1007/s10552-010-9515-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Type 2 diabetes mellitus has been associated with an increased risk of a variety of cancers in observational studies, but few have reported the relationship between diabetes and cancer risk in men and women separately. The main goal of this retrospective cohort study was to evaluate the sex-specific risk of incident overall and site-specific cancer among people with DM compared with those without, who had no reported history of cancer at the start of the follow-up in January 2000. During an average of 8 years of follow-up (SD = 2.5), we documented 1,639 and 7,945 incident cases of cancer among 16,721 people with DM and 83,874 free of DM, respectively. In women, DM was associated with an adjusted hazard ratio of 1.96 (95% CI: 1.53-2.50) and 1.41 (95% CI: 1.20-1.66) for cancers of genital organs and digestive organs, respectively. A significantly reduced HR was observed for skin cancer (0.38; 95% CI: 0.22-0.66). In men with DM, there was no significant increase in overall risk of cancer. DM was related with a 47% reduction in the risk of prostate cancer. These findings suggest that the nature of the association between DM and cancer depends on sex and specific cancer site.
引用
收藏
页码:879 / 887
页数:9
相关论文
共 67 条
[1]   Excess risk of primary liver cancer in patients with diabetes mellitus [J].
Adami, HO ;
Chow, WH ;
Nyren, O ;
Berne, C ;
Linet, MS ;
Ekbom, A ;
Wolk, A ;
McLaughlin, JK ;
Fraumeni, JF .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (20) :1472-1477
[2]   CANCER RISK IN PATIENTS WITH DIABETES-MELLITUS [J].
ADAMI, HO ;
MCLAUGHLIN, J ;
EKBOM, A ;
BERNE, C ;
SILVERMAN, D ;
HACKER, D ;
PERSSON, I .
CANCER CAUSES & CONTROL, 1991, 2 (05) :307-314
[3]  
ADAMI HO, 1996, JNCI-J NATL CANCER I, V88, P307
[4]   Is diabetes mellitus a risk factor for ovarian cancer? A case-control study in Utah and Washington (United States) [J].
Adler, AI ;
Weiss, NS ;
Kamb, ML ;
Lyon, JL .
CANCER CAUSES & CONTROL, 1996, 7 (04) :475-478
[5]   Risk Factors for Classical Kaposi Sarcoma on a Population-based Case-control Study in Sicily [J].
Anderson, Lesley A. ;
Lauria, Carmela ;
Romano, Nino ;
Brown, Elizabeth E. ;
Whitby, Denise ;
Graubard, Barry I. ;
Li, Yan ;
Messina, Angelo ;
Gafa, Lorenzo ;
Vitale, Francesco ;
Goedert, James J. .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (12) :3435-3443
[6]  
[Anonymous], 2002, Diabetes Care, V25, pS74
[7]  
[Anonymous], 312 WHO
[8]   INSULIN-LIKE GROWTH-FACTORS AND DIABETES [J].
BACH, LA ;
RECHLER, MM .
DIABETES-METABOLISM REVIEWS, 1992, 8 (03) :229-257
[9]  
BENDELAC J, 2009, MEMBERSHIP SICK FUND
[10]   Diabetes mellitus and pancreatic cancer mortality in a prospective cohort of United States adults [J].
Calle, EE ;
Murphy, TK ;
Rodriguez, C ;
Thun, MJ ;
Heath, CW .
CANCER CAUSES & CONTROL, 1998, 9 (04) :403-410