Type of serum collection tube does not impact neurofilament light chain levels

被引：2
|
作者：
Sotirchos, Elias S. [1 ]
Fitzgerald, Kathryn C. [1 ]
Smith, Matthew D. [1 ]
Vasileiou, Elena S. [1 ]
Resto, Yasmin [1 ]
Lord, Hannah-Noelle [1 ]
Mowry, Ellen M. [1 ]
Calabresi, Peter A. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2022年 / 59卷
基金：
美国国家卫生研究院;
关键词：
Neurofilament light chain; Serum; Collection tube; Biomarker;
D O I：
10.1016/j.msard.2022.103676
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Blood neurofilament light chain (NfL) has been reported to be a promising biomarker of neurological disease. NfL is predominantly measured in serum (sNfL), but there is a lack of reports regarding the effects of collection tubes on sNfL levels. We assessed sNfL levels using a novel immunoassay in 18 participants using 3 different types of serum collection tubes (no additive, with silica clot activator, and serum separator tubes). Variation observed in sNfL levels between samples from different collection tubes was similar to that observed in duplicate runs from the same tube. These findings support a lack of effect of type of serum collection tube on sNfL levels.
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Usefulness of serum neurofilament light chain in chronic inflammatory demyelinating polyradiculoneuropathy
    Llaurado, A.
    Garcia-Carmona, C.
    Restrepo-Vera, J. L.
    Aleman, J.
    Salvado, M.
    Sanchez-Tejerina, D.
    Sotoca, J.
    Seoane, J. L.
    Lainez, E.
    Gratacos-Vinola, M.
    Vidal-Taboada, J. M.
    Fissolo, N.
    Comabella, M.
    Raguer, N.
    Juntas-Morales, R.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2025, 470
  • [42] Serum neurofilament light chain in progressive supranuclear palsy
    Kaat, Laura Donker
    Meeter, Lieke H.
    Chiu, Wan Zheng
    Melhem, Shami
    Boon, Agnita J. W.
    Blennow, Kaj
    Zetterberg, Henrik
    van Swieten, John C.
    PARKINSONISM & RELATED DISORDERS, 2018, 56 : 98 - 101
  • [43] Association between serum neurofilament light chain and periodontitis
    Zhao, Jing
    Zhao, Panwen
    CLINICAL ORAL INVESTIGATIONS, 2024, 28 (07)
  • [44] The prognostic value of neurofilament light chain in serum Comment
    Sellebjerg, Finn
    Magyari, Melinda
    LANCET NEUROLOGY, 2022, 21 (03) : 207 - 208
  • [45] Elevated serum neurofilament light chain in children autism spectrum disorder: A case control study
    He, Wei-chao
    Zhang, Xu-jie
    Zhang, You-qi
    Zhang, Wei-jie
    NEUROTOXICOLOGY, 2020, 80 : 87 - 92
  • [46] Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder
    Paketci, Cem
    Ermis, Cagatay
    Sisman, Ali Riza
    Hiz, Semra
    Baykara, Burak
    Yis, Uluc
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2022, 52 (04) : 1041 - 1049
  • [47] Serum neurofilament light chain levels are correlated with the infarct volume in patients with acute ischemic stroke
    Ahn, June Woo
    Hwang, Jaechun
    Lee, Myunghoon
    Kim, Jae Hyoung
    Cho, Hee-Jin
    Lee, Ho-Won
    Eun, Mi-Yeon
    MEDICINE, 2022, 101 (39) : E30849
  • [48] Association of ethylene oxide exposure with serum neurofilament light chain levels among American adults
    Yang, Xiuwen
    Feng, Huaili
    You, Ting
    Liu, Zhaoyi
    Sun, Fanwei
    Chen, Chengzhi
    Qiu, Jingfu
    FRONTIERS IN PUBLIC HEALTH, 2025, 13
  • [49] Demographic and disease-related factors impact on cerebrospinal fluid neurofilament light chain levels in multiple sclerosis
    Revendova, Kamila Zondra
    Cucuzza, Chiara Starvaggi
    Manouchehrinia, Ali
    Khademi, Mohsen
    Bar, Michal
    Leppert, David
    Sandberg, Elisabeth
    Ouellette, Russell
    Granberg, Tobias
    Piehl, Fredrik
    BRAIN AND BEHAVIOR, 2023, 13 (01):
  • [50] Neurofilament Light Chain serum levels after Hypoxia-Ischemia in a newborn piglet model
    Kyng, Kasper Jacobsen
    Wellmann, Sven
    Lehnerer, Verena
    Hansen, Laerke Hjollund
    Kuhle, Jens
    Henriksen, Tine Brink
    FRONTIERS IN PEDIATRICS, 2023, 10
12345