Type of serum collection tube does not impact neurofilament light chain levels

被引：2
|
作者：
Sotirchos, Elias S. [1 ]
Fitzgerald, Kathryn C. [1 ]
Smith, Matthew D. [1 ]
Vasileiou, Elena S. [1 ]
Resto, Yasmin [1 ]
Lord, Hannah-Noelle [1 ]
Mowry, Ellen M. [1 ]
Calabresi, Peter A. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2022年 / 59卷
基金：
美国国家卫生研究院;
关键词：
Neurofilament light chain; Serum; Collection tube; Biomarker;
D O I：
10.1016/j.msard.2022.103676
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Blood neurofilament light chain (NfL) has been reported to be a promising biomarker of neurological disease. NfL is predominantly measured in serum (sNfL), but there is a lack of reports regarding the effects of collection tubes on sNfL levels. We assessed sNfL levels using a novel immunoassay in 18 participants using 3 different types of serum collection tubes (no additive, with silica clot activator, and serum separator tubes). Variation observed in sNfL levels between samples from different collection tubes was similar to that observed in duplicate runs from the same tube. These findings support a lack of effect of type of serum collection tube on sNfL levels.
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页数：3
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