Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy

被引：13

作者：

Loganadane, Gokoulakrichenane ^{[1
,2
]}

Kann, Benjamin H. ^{[1
]}

Park, Henry S. ^{[1
]}

Johnson, Skyler B. ^{[1
]}

Mehra, Saral ^{[3
]}

Judson, Benjamin L. ^{[3
]}

Bhatia, Aarti ^{[4
]}

Belkacemi, Yazid ^{[2
]}

Yarbrough, Wendell G. ^{[3
,5
]}

Burtness, Barbara ^{[4
]}

Husain, Zain A. ^{[1
,6
]}

机构：

[1] Yale Sch Med, Dept Therapeut Radiol, New Haven, CT USA

[2] Univ Paris Est Creteil UPEC, AP HP, Dept Radiat Oncol, Creteil, France

[3] Yale Sch Med, Dept Surg, Div Otolaryngol, New Haven, CT USA

[4] Yale Sch Med, Dept Internal Med, Div Med Oncol, New Haven, CT USA

[5] Univ N Carolina, Sch Med, Div Otolaryngol Head & Neck Surg, Chapel Hill, NC 27515 USA

[6] Univ Toronto, Odette Canc Ctr, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, Canada

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 09期

关键词：

Adjuvant radiation; refusal; head and neck cancer; recurrence; salvage therapy; SQUAMOUS-CELL-CARCINOMA; POSTOPERATIVE RADIOTHERAPY; SURVIVAL; CHEMOTHERAPY; IRRADIATION; RADIATION; REFUSAL; IMPACT;

D O I：

10.21873/anticanres.13674

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: This study aimed to evaluate the outcomes of patients with head and neck squamous cell carcinoma (HNSCC) who underwent resection and refused the recommended adjuvant therapy. Patients and Methods: Locoregional recurrence-free survival (LRRFS) and time to progression (TTP) were assessed in HNSCC patients treated with surgery who declined some or all adjuvant therapy (refusal group (RG)) compared to those who received the recommended adjuvant therapy (TG). Results: With a median follow-up of 23 months, the 2-year LRRFS was significantly lower in the 17 patients from the RG compared to the 152 patients from the TG: 23.1% vs. 69%, HR=0.30, 95% confidence incidence (CI)=0.15-0.59; p<0.001. The mean TTP was 12 months in the RG and was not reached in the TG (p<0.001). Conclusion: Patients with HNSCC who declined the recommended adjuvant therapy had a recurrence rate of 50% within a year.

引用

页码：4885 / 4890

页数：6

共 16 条

[1] MANAGEMENT OF CERVICAL LYMPH-NODE METASTASES IN SQUAMOUS CELL-CARCINOMA OF TONSILLAR FOSSA, BASE OF TONGUE, SUPRAGLOTTIC LARYNX, AND HYPOPHARYNX [J].

BARKLEY, HT ;

JESSE, RH ;

LINDBERG, RD ;

FLETCHER, GH .

AMERICAN JOURNAL OF SURGERY, 1972, 124 (04) :462-&

[2]

BARTELINK H, 1983, CANCER-AM CANCER SOC, V52, P1008, DOI 10.1002/1097-0142(19830915)52:6<1008::AID-CNCR2820520613>3.0.CO

[3]

2-B

[4] Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer [J].

Bernier, J ;

Domenge, C ;

Ozsahin, M ;

Matuszewska, K ;

Lefèbvre, JL ;

Greiner, RH ;

Giralt, J ;

Maingon, P ;

Rolland, F ;

Bolla, M ;

Cognetti, F ;

Bourhis, J ;

Kirkpatrick, A ;

van Glabbeke, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (19) :1945-1952

[5] Underuse of Breast Cancer Adjuvant Treatment: Patient Knowledge, Beliefs, and Medical Mistrust [J].

Bickell, Nina A. ;

Weidmann, Jessica ;

Fei, Kezhen ;

Lin, Jenny J. ;

Leventhal, Howard .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (31) :5160-5167

[6] Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck [J].

Cooper, JS ;

Pajak, TF ;

Forastiere, AA ;

Jacobs, J ;

Campbell, BH ;

Saxman, SB ;

Kish, JA ;

Kim, HE ;

Cmelak, AJ ;

Rotman, M ;

Machtay, M ;

Ensley, JF ;

Chao, KSC ;

Schultz, CJ ;

Lee, N ;

Fu, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (19) :1937-1944

[7] ANALYSIS OF THE PARAMETERS RELATING TO FAILURES ABOVE THE CLAVICLES IN PATIENTS TREATED BY POSTOPERATIVE IRRADIATION FOR SQUAMOUS-CELL CARCINOMAS OF THE ORAL CAVITY OR OROPHARYNX [J].

FELDMAN, M ;

FLETCHER, GH .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (01) :27-30

[8] Refusal of Radiation Therapy and Its Associated Impact on Survival [J].

Hamidi, Maryam ;

Moody, John S. ;

Kozak, Kevin R. .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2010, 33 (06) :629-632

[9] Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers [J].

Johnson, Skyler B. ;

Park, Henry S. ;

Gross, Cary P. ;

Yu, James B. .

JAMA ONCOLOGY, 2018, 4 (10) :1375-1381

[10] Use of Alternative Medicine for Cancer and Its Impact on Survival [J].

Johnson, Skyler B. ;

Park, Henry S. ;

Gross, Cary P. ;

Yu, James B. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2018, 110 (01) :121-124

← 1 2 →