Maternal caregiving and DNA methylation in human infants and children: Systematic review

被引：47
作者：
Provenzi, Livio [1 ]
Brambilla, Maddalena [1 ]
di Minico, Giunia Scotto [1 ]
Montirosso, Rosario [1 ]
Borgatti, Renato [2 ]
机构：
[1] Sci Inst IRCCS E Medea, Ctr At Risk Infant 0 3, Bosisio Parini, Lecco, Italy
[2] Sci Inst IRCCS E Medea, Child Neuropsychiat & Neurorehabil Unit, Bosisio Parini, Lecco, Italy
来源：
GENES BRAIN AND BEHAVIOR | 2020年 / 19卷 / 03期
关键词：
behavioral epigenetics; DNA methylation; early adversity; maternal caregiving; maternal depression; NEUROTROPHIC FACTOR BDNF; EARLY-LIFE ADVERSITY; GENDER-DIFFERENCES; EPIGENETIC MECHANISMS; SLC6A4; METHYLATION; PROMOTER REGION; CARE; STRESS; BLOOD; ASSOCIATIONS;
D O I：
10.1111/gbb.12616
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The integration of behavioral epigenetics' principles (eg, DNA methylation) into the study of human infants' development has mainly focused on the effects of early adverse exposures, paying less attention to protective caregiving experiences. The present review focused on DNA methylation linked to variations in maternal behavior in human infants and children. Literature search occurred on three databases (PubMed, Scopus and Web of Science) and 11 records were selected. Key variables were abstracted from each article including: sample size and characteristics, time and type of maternal caregiving behavior exposure, time and locus of methylation biomarker, presence/absence, time and type of adverse exposure. Six out of eleven records documented the predictive effect of maternal caregiving on DNA methylation, whereas the remaining five reported on the role of maternal behavior as an influencing factor of the adversity-to-methylation link. Consistent with evidence from the animal model, the quality of maternal caregiving in humans (a) might be associated with variations in DNA methylation status of specific genes involved in socio-emotional development and (b) might partially buffer the association between early adversities and epigenetic variations in infants and children. Current evidence suggests that the quality of maternal caregiving can contribute to behavioral development trajectories of human infants and children at least partially through epigenetic regulation. Open questions and methodological aspects are discussed to guide future human developmental research in behavioral epigenetics.
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页数：11
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