Association between genetic variants in ZNF365 and inflammatory bowel disease risk in Caucasians: a meta-analysis and trial sequential analysis

被引：4

作者：

Wu, Peng-bo ^{[1
]}

Zhang, Yu ^{[2
]}

Nie, Gang ^{[3
]}

Huang, Xu ^{[1
]}

Yu, Yuan-jie ^{[1
]}

Yin, An-ning ^{[1
]}

Zhou, Rui ^{[1
]}

He, Chun-ping ^{[1
]}

Wang, Peng ^{[4
]}

机构：

[1] Wuhan Univ, Dept Gastroenterol, Renmin Hosp, 238 Jiefang Rd, Wuhan 436500, Hubei, Peoples R China

[2] Wuhan Univ, Infrastruct Management Dept, Renmin Hosp, Wuhan, Hubei, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Dermatovenereol, Shenzhen, Guangdong, Peoples R China

[4] Wuhan Univ, Dept Gastrointestinal Surg, Renmin Hosp, Wuhan, Hubei, Peoples R China

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2021年 / 17卷 / 08期

关键词：

ZNF365; polymorphism; crohn's disease; ulcerative colitis; meta-analysis; GENOME-WIDE ASSOCIATION; CROHNS-DISEASE; SUSCEPTIBILITY LOCI; POLYMORPHISMS; MUTATIONS; MULTIPLE; CHILDREN; REPEAT; CANCER;

D O I：

10.1080/1744666X.2021.1939012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective The published studies regarding the relationships between zinc finger 365 (ZNF365) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasians have yielded conflicting results. Therefore, we performed a meta-analysis to clarify this issue. Methods The Electronic databases of PubMed, Web of Science, Wiley Online Library, and EMBASE were searched for eligible studies up to 31 November 2020. The quality of eligible studies was evaluated using the Newcastle-Ottawa Scale. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under different genetic models were calculated to assess the strength of associations. Results A total of 22 relevant case-control studies with 9542 ulcerative colitis (UC) patients and 13,886 controls, as well as 13,651 Crohn's disease (CD) patients and 15,256 controls, were involved in our meta-analysis. rs10761659 polymorphism significantly decreased CD and UC risk (except for the heterozygous model and the dominant model in UC), and rs10995271 polymorphism was significantly associated with UC (except for the heterozygous model and dominant model) rather than CD. Conclusions The meta-analysis demonstrated that the rs10761659 polymorphism might be a protective factor for both UC and CD in Caucasians, while the rs10995271 polymorphism might be a risk factor for UC rather than CD in Caucasians.

引用

页码：915 / 921

页数：7

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