Design, synthesis and DNA/RNA binding studies of nucleic acids comprising stereoregular and acyclic polycarbamate backbone: polycarbamate nucleic acids (PCNA)

被引：16

作者：

Madhuri, Vangala ^{[1
]}

Kumar, Vaijayanti A. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 16期

关键词：

CARBAMATE INTERNUCLEOSIDE LINKAGES; ANALOGS; RNA; OLIGONUCLEOTIDES; SEQUENCE; HYBRIDIZATION; NUCLEOSIDE; PNA; DNA; RECOGNITION;

D O I：

10.1039/c003405n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The designed, chiral, acyclic polycarbamate nucleic acids (PCNA) exhibited sequence and orientation specific binding to nucleic acids. Complexes of PCNA with DNA were as stable as PNA:DNA complexes and those with RNA were as stable as natural DNA:RNA complexes.

引用

页码：3734 / 3741

页数：8

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