New Approaches to Inhibiting Platelets and Coagulation

被引：35

作者：

Depta, Jeremiah P. ^{[1
]}

Bhatt, Deepak L.

机构：

[1] Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷

关键词：

antiplatelet; anticoagulation; antithrombotic therapy; atherothrombosis; acute coronary syndrome; venous thromboembolism; PERCUTANEOUS CORONARY INTERVENTION; ELEVATION MYOCARDIAL-INFARCTION; DUAL-ANTIPLATELET THERAPY; ASSOCIATION TASK-FORCE; DRUG-ELUTING STENTS; PRASUGREL; 10; MG; DOUBLE-BLIND; ISCHEMIC EVENTS; CARDIOVASCULAR-DISEASE; ANTITHROMBOTIC THERAPY;

D O I：

10.1146/annurev-pharmtox-010814-124438

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ischemic heart disease and stroke are major causes of death and morbidity worldwide. Coronary and cerebrovascular events are a consequence of thrombus formation caused by atherosclerotic plaque rupture or embolism, both of which result from platelet activation and aggregation and thrombin-mediated fibrin generation via the coagulation cascade. Current and emerging antiplatelet and anticoagulant agents are evolving rapidly. The use of aspirin for primary prevention continues to be controversial, as are the doses appropriate for secondary prevention. Development of new oral and intravenous adenosine diphosphate P2Y(12) inhibitors and novel antiplatelet agents continues to transform the landscape of antiplatelet therapy. Oral anticoagulation has advanced with the use of direct thrombin and factor Xa inhibitors that do not require therapeutic monitoring. In this review, we discuss the pharmacology and growing clinical evidence for traditional and new antiplatelet and anticoagulant therapies.

引用

页码：373 / 397

页数：25

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