Chemoselective and Regiospecific Suzuki Coupling on a Multisubstituted sp3-Carbon in 1,1-Diborylalkanes at Room Temperature

被引：180

作者：

Endo, Kohei ^{[1
]}

Ohkubo, Takahiro ^{[2
]}

Hirokami, Munenao ^{[2
]}

Shibata, Takanori ^{[2
]}

机构：

[1] Waseda Inst Adv Study, Shinjuku Ku, Tokyo 1698050, Japan

[2] Waseda Univ, Dept Chem & Biochem, Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 32期

基金：

日本学术振兴会;

关键词：

CROSS-COUPLINGS; ACID-DERIVATIVES; MILD CONDITIONS; BORONIC ACIDS; ALKYL-HALIDES; PALLADIUM; ARYL; ESTERS; HYDROBORATION; ALKENYLBORONATE;

D O I：

10.1021/ja105176v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The palladium-catalyzed Suzuki-Miyaura cross-coupling on a multisubstituted sp(3)-carbon in 1,1-diborylalkanes was achieved at room temperature. The generation of a monoborate intermediate by virtue of the adjacent B atom could result in the chemoselective coupling reaction under ambient conditions.

引用

页码：11033 / 11035

页数：3

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