Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression

被引：222
作者：
Christofori, G [1 ]
机构：
[1] Univ Basel, Inst Biochem & Genet, Dept Clin Biol Sci, CH-4051 Basel, Switzerland
来源：
EMBO JOURNAL | 2003年 / 22卷 / 10期
关键词：
cadherin; cell adhesion; integrin; metastasis; signalling;
D O I：
10.1093/emboj/cdg228
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Changes in cell-cell and cell-matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.
引用
收藏
页码：2318 / 2323
页数：6
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