Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression

被引:222
作者
Christofori, G [1 ]
机构
[1] Univ Basel, Inst Biochem & Genet, Dept Clin Biol Sci, CH-4051 Basel, Switzerland
关键词
cadherin; cell adhesion; integrin; metastasis; signalling;
D O I
10.1093/emboj/cdg228
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Changes in cell-cell and cell-matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.
引用
收藏
页码:2318 / 2323
页数:6
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