Synthetic Studies on Glycosphingolipids from Protostomia Phyla: Synthesis of Glycosphingolipids from the Parasite Schistosoma mansoni

被引：9
|
作者：
Kanaya, Takayuki [1 ]
Yagi, Satomi [1 ]
Schweizer, Frank [2 ]
Takeda, Tadahiro [1 ]
Kiuchi, Fumiyuki [1 ]
Hada, Noriyasu [1 ]
机构：
[1] Keio Univ, Fac Pharm, Minato Ku, Tokyo 1058512, Japan
[2] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 06期
关键词：
glycosphingolipid; Schistosoma mansoni; schisto-core; chemical synthesis; LEWIS-X; BIOLOGICAL-ACTIVITIES; GLYCOSYLATION; DEACETYLATION; GLYCOLIPIDS; ANALOGS; EGGS;
D O I：
10.1248/cpb.58.811
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. These structures differ significantly from those of other parasites and exhibit a unique structural motif termed "schisto-core" consisting of GalNAc beta 1 -> 4Glc beta 1 -> sequence. We have synthesized glycosphingolipids, beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (1), beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (2) and beta-D-Galp-(1 -> 4)-beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (3).
引用
收藏
页码：811 / 817
页数：7
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