Synthetic Studies on Glycosphingolipids from Protostomia Phyla: Synthesis of Glycosphingolipids from the Parasite Schistosoma mansoni

被引：9

作者：

Kanaya, Takayuki ^{[1
]}

Yagi, Satomi ^{[1
]}

Schweizer, Frank ^{[2
]}

Takeda, Tadahiro ^{[1
]}

Kiuchi, Fumiyuki ^{[1
]}

Hada, Noriyasu ^{[1
]}

机构：

[1] Keio Univ, Fac Pharm, Minato Ku, Tokyo 1058512, Japan

[2] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 06期

关键词：

glycosphingolipid; Schistosoma mansoni; schisto-core; chemical synthesis; LEWIS-X; BIOLOGICAL-ACTIVITIES; GLYCOSYLATION; DEACETYLATION; GLYCOLIPIDS; ANALOGS; EGGS;

D O I：

10.1248/cpb.58.811

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. These structures differ significantly from those of other parasites and exhibit a unique structural motif termed "schisto-core" consisting of GalNAc beta 1 -> 4Glc beta 1 -> sequence. We have synthesized glycosphingolipids, beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (1), beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (2) and beta-D-Galp-(1 -> 4)-beta-D-GlcNAcp-(1 -> 3)-beta-D-GalNAcp-(1 -> 4)-beta-D-Glcp-(1 -> 1)Cer (3).

引用

页码：811 / 817

页数：7

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