Microwave-assisted synthesis and biological activity of 3-alkyl/aryl-6-(1-chloro-3,4-dihydronaphth-2-yl)-5,6-dihydro-s-triazolo [3,4-b] [1,3,4] thiadiazoles

被引:0
作者
Kamotra, Poonam
Gupta, Avinash K.
Gupta, Rajive [1 ]
Somal, P.
Singh, S.
机构
[1] Univ Jammu, Dept Chem, Jammu 180006, India
[2] Reg Res Lab, Dept Microbiol, Jammu 180001, India
[3] Reg Res Lab, Dept Pharmacol, Jammu 180001, India
来源
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2007年 / 46卷 / 06期
关键词
3-alkyl/aryl-6-(1-chloro-3,4-dihydronaphth-2-yl)-5,6-dihydro-s-triazolo[3,4-b][1,3,4]thiadiazoles; p-TsOH; microwave irradiation; rate enhancement; specific microwave effect; biological activity;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
3-Alkyl/aryl-6-(1-chloro-3,4-dihydronaphth-2-yl)-5,6-dihydro-s-triazolo[3,4-b][1,3,4]thaidiazoles 3 have been synthesised by the condensation of 5-alkyl/aryl-4-amino-3-mercapto-1,2,4-triazoles 2 with 1-chloro-2-formyl-3,4-dihydronaphthalene 1 in presence of catalytic quantity of p-TsOH under microwave irradiation. Rate enhancement and improvement in yeilds, characteristics of synthesis under microwave irradiation, have been observed. The compounds synthesised have been characterised and screened for their antibacterial, antifungal, antiinflammatory and antioxidant activity.
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页码:980 / 984
页数:5
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