Diterpenoids from Euphorbia neriifolia and Their Related Anti-HIV and Cytotoxic Activity

被引：17

作者：

Li, Jian-Chun ^{[1
]}

Feng, Xiao-Yi ^{[1
]}

Liu, Dan ^{[1
]}

Zhang, Zhi-Jun ^{[1
]}

Chen, Xuan-Qin ^{[1
]}

Li, Rong-Tao ^{[1
]}

Li, Hong-Mei ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2019年 / 16卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Euphorbia neriifolia; ent-atisane diterpenoids; anti-HIV; cytotoxic activity;

D O I：

10.1002/cbdv.201900495

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC50 were 6.6 +/- 3.2 and 6.4 +/- 2.5 mu g mL(-1), respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 mu m, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50=0.01 mu m), while it did not show any cytotoxicity against HepG2/Adr cell lines.

引用

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