Sequence analysis of pDN571, a plasmid encoding novel bacteriocin production in M-type 57 Streptococcus pyogenes

被引：15

作者：

Heng, NCK ^{[1
]}

Burtenshaw, GA ^{[1
]}

Jack, RW ^{[1
]}

Tagg, JR ^{[1
]}

机构：

[1] Univ Otago, Dept Microbiol & Immunol, Dunedin, New Zealand

来源：

PLASMID | 2004年 / 52卷 / 03期

关键词：

Streptococcus pyogenes; M-type; 57; bacteriocin production; streptococcin A-M57; rolling-circle replication; pC194/pU-B110; family;

D O I：

10.1016/j.plasmid.2004.08.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Production of the novel bacteriocin streptococcin A-M57 (SA-M57) by Streptococcus pyogenes strains of M-protein type 57 is plasmid-associated. Plasmid pDN571 (3351 bp) harbored by S. pyogenes 71-724, the prototype M-type 57 strain, has been completely sequenced and contains three putative open reading frames (repA, scnM57 and ORF3). In addition, the double-strand and single-strand (SSO) origins of replication were identified. Analysis of the replication-associated genetic elements places pDN571 in the ubiquitous pC194/pUB110 family of rolling-circle plasmids. The SSO of pDN571 is of the ssoA type. SA-M57 (encoded by scnM57) is synthesized as a secreted 179-amino acid polypeptide with a 27-residue secretion signal peptide and has no homology to proteins of known function. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：225 / 229

页数：5

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