Molecular Targets of Cannabinoids Associated with Depression

被引：6

作者：

Paudel, Pradeep ^{[1
]}

Ross, Samir ^{[1
,2
]}

Li, Xing-Cong ^{[1
,2
]}

机构：

[1] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Dept Biomol Sci, University, MS 38677 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2022年 / 29卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Cannabinoids; molecular targets; depression; CB receptors; MAO; NMDA receptors; GABA receptors; CCK receptors; MONOAMINE-OXIDASE-A; GAMMA-AMINOBUTYRIC-ACID; ANTIDEPRESSANT-LIKE; CB2; RECEPTOR; PARKINSONS-DISEASE; BETA-CARYOPHYLLENE; PREFRONTAL CORTEX; PHARMACOLOGICAL EVALUATION; ENDOGENOUS CANNABINOIDS; ENDOCANNABINOID SYSTEM;

D O I：

10.2174/0929867328666210623144658

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel therapeutic strategies are needed to address depression, a major neurological disorder affecting hundreds of millions of people worldwide. Cannabinoids and their synthetic derivatives have demonstrated numerous neurological activities and may have the potential to be developed into new treatments for depression. This review highlights cannabinoid (CB) receptors, monoamine oxidase (MAO), N-methyl-D-aspartate (NMDA) receptor, gamma-aminobutyric acid (GABA) receptor, and cholecystokinin (CCK) receptor as key molecular targets of cannabinoids that are associated with depression. The anti-depressant activity of cannabinoids and their binding modes with cannabinoid receptors are discussed, providing insights into rational design and discovery of new cannabinoids or cannabimimetic agents with improved druggable properties.

引用

页码：1827 / 1850

页数：24

共 227 条

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