Nuclear Functions of Actin

被引:117
作者
Visa, Neus [1 ]
Percipalle, Piergiorgio [2 ]
机构
[1] Stockholm Univ, Dept Mol Biol & Funct Genom, SE-10691 Stockholm, Sweden
[2] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden
基金
瑞典研究理事会;
关键词
RNA-POLYMERASE-II; CHROMATIN REMODELING COMPLEX; ON-TRANSIENT-A; MESSENGER-RNA; MYOSIN-I; BINDING PROTEINS; TRANSCRIPTION INITIATION; DEPENDENT TRANSCRIPTION; GENE-EXPRESSION; SPLICING FACTOR;
D O I
10.1101/cshperspect.a000620
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Actin participates in several essential processes in the cell nucleus. Even though the presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes that require actin have been only recently identified. Actin is part of chromatin remodeling complexes; it is associated with the transcription machineries; it becomes incorporated into newly synthesized ribonucleoproteins; and it influences long-range chromatin organization. As in the cytoplasm, nuclear actin works in conjunction with different types of actin-binding proteins that regulate actin function and bridge interactions between actin and other nuclear components.
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页数:13
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