Synthesis of new N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid derivatives and their evaluation as anticancer agents

被引：26

作者：

Cocco, MT ^{[1
]}

Congiu, C ^{[1
]}

Lilliu, V ^{[1
]}

Onnis, V ^{[1
]}

机构：

[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

anthranilic acid; anticancer activity; antitumoral drugs; pyridine derivatives;

D O I：

10.1016/j.bmcl.2004.09.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid 6 and a series of its ester and amide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against human cancer cells. Ester derivatives 13 and 18 exhibited potent growth inhibitory activity with GI(50) values at nanomolar concentrations. Among amide derivatives, N-anthraniloylglycinate 19 shown moderate inhibitory activity in the full panel cancer cell line screening. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5787 / 5791

页数：5

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